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A Prescription for Beautiful and Healthy Legs

By Robert Haas, MS

September 2009

By Robert Haas, MS

Healing Venous Leg Ulcers with Micronized Diosmin

Venous ulcers affect 500,000 Americans every year and account for 80 to 90% of all leg ulcers. They typically occur in people with a history of leg swelling, varicose veins, or a history of blood clots in either the superficial or the deep veins of the legs. Ulcers may affect one or both legs.

Healing Venous Leg Ulcers with Micronized Diosmin

Venous ulcers can occur on either side of the lower leg, usually above the ankle and below the knee. A shallow wound with a reddish base develops when the leg veins’ valves become damaged and fail to adequately move blood back toward the heart. Some ulcers can be covered with pale yellow fibrous tissue and exude pus and extracellular fluid if the ulcer becomes infected.

Studies show that micronized diosmin helps heal leg ulcerations by inhibiting the synthesis of inflammatory prostaglandins and free radicals.15 Micronized diosmin also decreases microvascular leakage and inhibits white blood cell trapping and migration.16 One study found that treatment with micronized diosmin led to complete healing of infected leg ulcers.17

A multicenter, randomized, controlled trial tested micronized diosmin in addition to standard compression stocking therapy versus placebo for two months in patients with leg ulcers.18 The study group consisted of 140 men and women ranging in age from 18 to 85 years who were undergoing standardized local care of leg ulcer. A significantly larger number of patients (47% in the diosmin group vs. 28% in the placebo group) experienced complete healing of venous ulcers at the end of six months.

Micronized Diosmin for Lymphedema
  • Lymphedema is an abnormal swelling that occurs when a blockage in the lymphatic system prevents the lymph fluid in an arm or leg from draining adequately.
  • Micronized diosmin has been shown to improve lymphatic drainage by promoting lymphatic contractions, by increasing the number of functional lymphatic capillaries, and by decreasing the diameter of lymphatic capillaries and the intralymphatic pressure.14,21,22
  • One study analyzed micronized diosmin as a treatment for upper-limb lymphedema secondary to conventional therapy for breast cancer. Results showed improvement of all symptoms and reduction of arm swelling.23
  • Another study suggested a beneficial therapeutic activity of micronized diosmin in female breast cancer patients affected with severe lymphedema secondary to conventional breast cancer therapies.24

A number of randomized prospective studies using diosmin as an adjunct to conventional treatment demonstrate the efficacy of the supplement in helping to heal leg ulcers. In a research review, conventional treatment (compression and local care) in addition to a daily dose of diosmin was compared with conventional treatment plus placebo or with conventional treatment alone. The results showed a clear benefit of adjunctive micronized diosmin treatment over conventional therapy alone.10 These results confirm that venous ulcer healing is accelerated by adjunctive treatment with diosmin.


Micronized diosmin is the most widely used drug (used by tens of millions of European women) to achieve shapelier, smoother and more well-defined looking legs. Micronized diosmin rapidly improves the symptoms and appearance of varicose and spider veins.

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Of all the drugs used clinically for leg swelling reduction, only micronized diosmin has shown to be effective in clinical trials involving leg swelling (edema) associated with venous disorders. Edema creates unsightly ‘cankles,’ a term used to denote the loss of contour between calves and ankles.

Micronized diosmin is the only oral treatment shown to be effective from the earliest symptoms of chronic venous disease up to the most severe stages. Micronized diosmin is highly effective at improving the appearance of cosmetically unattractive venous disorders, including varicose veins, spider veins, leg ulcers, and swollen ankles.

Micronized diosmin possesses a unique and clinically proven mode of action that addresses all the disabling aspects of venous disease affecting the veins, lymph glands, and microcirculation. In patients suffering from CVI, diosmin provides significant relief from pain, heavy legs, and cramps.

No other oral medication except micronized diosmin has ever been shown to relieve the symptoms or reactionary bleeding experienced by patients after hemorrhoidectomy. Diosmin also provides relief from lymphedema following conventional treatment for breast cancer.

Micronized diosmin enjoys an outstanding safety record unrivaled by any other drug used to treat venous disorders.The overwhelming majority of published studies show that diosmin is generally nontoxic at recommended doses, including studies involving pregnancy, and is relatively free from drug interactions. However, those who are pregnant or who take any prescription medications should check with a physician before taking micronized diosmin.

Preparation “D” (Diosmin) For Hemorrhoids
  • Inflamed hemorrhoids have been called the ‘varicose veins’ of the anus and rectum.

  • A number of large clinical trials have shown micronized diosmin to be effective in mitigating the acute and chronic symptoms associated with inflamed hemorrhoids.
  • A double-blind, placebo-controlled study of 120 patients showed improvement of pain, discharge, swelling, and bleeding when treated with micronized diosmin twice a day for two months.19
  • No oral medication besides micronized diosmin has ever been shown to reduce the pain, tenesmus, pruritus, or reactionary bleeding that patients may experience after hemorrhoidectomy (surgical treatment of hemorrhoids).
  • A study involving pregnant women with acute hemorrhoids who were treated with micronized diosmin for eight weeks before delivery and four weeks after delivery showed that micronized diosmin was both effective and safe for mother and fetus.20

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-800-226-2370.


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