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Life Extension Magazine

Reverse Age-Related Weight Gain

By William Faloon

Take Control of Your Fat-regulating Factors

Fat cells (called adipocytes) secrete leptin, a hormone that tells your brain you’ve eaten enough. Leptin also facilitates the breakdown of stored (triglyceride) fat in our adipocytes.19,20

Overweight people have higher blood levels of leptin, indicating their cells have become resistant to the leptin that enables thin people to not put on so many fat pounds.21-23

Irvingia gabonensis is a West African plant extract that has been shown to help support leptin sensitivity in overweight people. When study subjects take Irvingia, their leptin levels drop, indicating that their cells are picking up the leptin and utilizing its beneficial fat-regulating properties. Study subjects taking Irvingia report consuming fewer calories, which makes sense, based on the enhanced leptin sensitivity brought about by this plant extract.6

In a double-blind study on 60 overweight volunteers, those taking Phaseolus vulgaris lost 6.5 pounds of weight and 1.2 inches in waist size compared with 0.8 pounds and 0.2 inches in the placebo group.

Researchers know that more than leptin sensitivity is involved in Irvingia’s weight loss abilities. It turns out that Irvingia also has alpha-amylase-inhibiting properties24 similar to Phaselolus vulgaris. Inhibiting amylase helps slow the rate of carbohydrate absorption, thus reducing the caloric impact of starchy-sugary foods.

Scientific data suggests that Irvingia also helps support healthy adiponectin levels.6 Adiponectin is a hormone that helps maintain insulin sensitivity of energy-producing cells. Large fat cells found on overweight people produce less adiponectin. These means these individuals need to be concerned about maintaining enough adiponectin to support insulin sensitivity, something normally lost as we age.

Triple the Weight Loss Effects of Calorie Reduction

The majority of body fat consists of triglycerides that are stored in our fat cells. A reason that weight loss and triglyceride reduction go hand-in-hand is that triglycerides make up the bulk of our fat storage. We get triglycerides directly from the fat we eat and also from conversion of excess glucose in our blood to triglycerides that is stored in fat cells.

Glucose is converted to triglycerides storage in fat cells by an enzyme called glycerol-3-phosphate dehydrogenase. Irvingia inhibits glycerol-3-phosphate dehydrogenase, thus reducing the amount of ingested sugars that are converted to body fat.25

So Irvingia functions to reduce stored body fat by:

  1. Up-regulating the expression of adiponectin, thereby improving insulin sensitivity.6
  2. Restoring the dual weight control effects of leptin.6
  3. Inhibiting the glycerol-3-phosphate dehydrogenase, thereby reducing fatty acid storage in fat cells.25
  4. Inhibiting alpha-amylase, thus reducing the amount of ingested starches that will be absorbed as glucose.6,24,25

The most impressive published study on Irvingia demonstrated beneficial effects on leptin blood levels, followed by a weight loss of over 20 pounds on average in 10 weeks. This kind of impressive result, however, has not consistently been shown in those who take Irvingia by itself.6

How Green Tea Enhanced Effects of Reduced Calorie Intake
How Green Tea Enhanced Effects of Reduced Calorie Intake

When we eat less, our metabolism slows down, which causes our body to go into a fat conservation mode. By consuming this green tea phytosome and reducing calorie ingestion and/or absorption, your basal metabolic rate is increased, so more fat pounds are lost than if you only consumed fewer calories.26

Irvingia is included in the new powdered drink mix formula to better enable people to control critical fat regulators (leptin, adiponectin, and glycerol-3-phosphate dehydrogenase) while also further inhibiting the amylase enzyme.

Triple the Weight Loss Effects of Calorie Reduction

As we age, we lose the ability to efficiently burn ingested food as energy. The result of excess calorie intake is unwanted body fat stores.

Triple the Weight Loss Effects of Calorie Reduction

The encouraging news is that a proprietary green tea delivery system has been documented to substantially enhance the weight loss effects of eating healthier—while also trimming belly fat.

Green tea’s weight loss benefits are attributed to polyphenol compounds that increase metabolic energy expenditure and calorie burning. The problem is getting a sufficient amount of green tea’s polyphenols absorbed into the blood.

A group of researchers created a proprietary green tea phytosome that increased the capacity of polyphenols to be absorbed into the blood.

In a human study using this green tea phytosome, the weight-loss effects were greater than for any other compound we have ever observed. This study involved 100 overweight subjects. Half received the green tea phytosome. Both groups were placed on reduced calorie diets of approximately 1,850 calories/day for men and 1,350 calories/day for women. This is not a starvation diet (especially for the men).4

After three months on the reduced calorie diet the control group lost 9.9 pounds. The group taking the green tea phytosome, however, lost 30.1 pounds. This was triple the weight loss seen in the control group who did not receive the green tea phytosome.4

There was a 10% reduction in the abdominal fat pad in the green tea phytosome group compared with only 5% reduction in the control group. Male participants showed a 14% reduction in abdominal circumference compared with 7% reduction in the control group.4

This study confirmed that people can lose weight (9.9 pounds) by eating fewer calories. But when this green tea phytosome was added, the amount of weight shed tripled—while twice as much abdominal fat disappeared.4

The remarkable effect of this proprietary green tea compound to remove 30.1 pounds of weight is attributed to its ability to increase resting metabolic rate while reducing the absorption of dietary fats.4 This green tea phytosome is thus an ideal nutrient to take with other compounds that reduce the rate of calorie absorption such as propolmannan and Phaseolus vulgaris.

If you are seriously seeking to shed excess body fat, it makes sense to avail yourself to the weight loss-amplifying effects of this proprietary green tea phytosome.

Rationale of Combining Four Ingredients into One Powdered Drink Mix

A new powdered drink mix provides the following nutrients at similar doses used in human clinical weight loss studies:

  1. Propolmannan
  2. Phaseolus vulgaris
  3. Irvingia
  4. Green Tea phytosome

The rationale for selecting this particular combination is to enable overweight and obese individuals to modestly decrease their caloric intake without hunger (by enhancing leptin sensitivity) and reduce the amount of dietary fats and carbohydrates that are absorbed (using propolmannan and Phaseolus vulgaris). This then sets the stage for the remarkable benefits of the green tea phytosome to function in tandem with the reduced calorie burden to facilitate optimal weight loss, especially in the abdominal region.

To test this hypothesis, we took a group of overweight people who had failed all previous attempts to lose weight. These treatment-resistant individuals took a scoop of a powdered drink mixed with water 15-30 minutes before meals. After eight weeks, they lost an average of almost 12 pounds.

It would appear that continued use of this powdered drink mix before meals, along with taking individualized steps to address one’s obesity-inducers, will result in a sustained reduction of body fat mass.

For those who visit our Life Extension Nutrition Center in Fort Lauderdale, Florida, we have a scuba diver weight belt that weighs 12 pounds. When a customer trivializes 12 pounds of weight loss in eight weeks, we let them walk around for 60 seconds wearing this weight belt. They quickly realize how heavy twelve pounds is and how much better they will feel after they shed this much body fat.


Aging humans seldom understand the magnitude of excess calories ingested each day. They too often think they are only eating a little more than they should.

The reality is that most of us consume far more food than our body can utilize for energy production. The result is an accumulation of unsightly fat masses that unleash deadly pro-inflammatory cytokines along with an inability to maintain glucose control and healthy blood lipid levels.

With the advent of nutritional compounds that impede dietary fat and carbohydrate absorption, manage regulators of fat storage like leptin, and boost resting metabolic rate—aging humans can realistically expect to start shedding excess pounds and inches in a safe and sustainable manner.

The challenge for all of us is to remember that excess calories are poison. We can either avoid the poison by drastically reducing our calorie intake, or take the nutrients described in this article before large meals to mitigate the effects of ingested calories, i.e., how many are absorbed and how many of the excess calories that make it into your bloodstream convert to body fat.

We suspect dedicated health enthusiasts will consider a little of both, meaning eating a little less and blunting the effects of the excess by taking the appropriate nutrients before most meals.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.

When Good Metabolisms Go Bad

Obesity and type 2 diabetes have reached epidemic proportions. The simple explanation is to blame our increasingly sedentary lifestyles, nutrient depleted, highly processed foods, and a culture that often proclaims that bigger is always better—including the size of food portions. But the harsh reality is that as we age, we are unable to efficiently convert ingested calories into energy production for a variety of reasons.

Obesity is a cause of many serious health problems. Adipose tissue broadcasts highly inflammatory immune substances such as interleukin-6 and interleukin-1-beta that in turn increase C-reactive protein blood levels.

Chronically elevated levels of inflammation are associated with increased risk of cardiovascular disease,27 arthritis and connective tissue disorders,28 and fatigue and pain.

Obesity and inflammation often go hand in hand. Conversely, reducing weight with sensible approaches sets in motion a positive spiral of reduced inflammation and a spectrum of associated health benefits.

Caution: The remarkable fat-binding properties of propolmannan have one downside. Critical fat soluble nutrients like omega-3s, gamma tocopherol, along with vitamins D and K may not be fully absorbed. We suggest taking these fat-soluble nutrients at a different time of the day than propolmannan-containing supplements. Members typically obtain their gamma E and vitamin K in the Super Booster formula, along with a 5,000 IU vitamin D3 capsule and four softgels daily of Super Omega-3. For those who don’t use the Super Booster, we have formulated a new Essential Fat-Soluble Nutrients formula that contains in one softgel:

Vitamin D

7,000 IU

Vitamin K2 (as long-acting MK-7)

100 mcg

Gamma tocopherol

210 mg

DHA (from fish oil)

500 mg

This one softgel enables members to eliminate use of separate products. Three to four of Super Omega-3 should still be taken to obtain optimal levels of critical EPA/DHA fatty acids. A more complete description of the new Essential Fat-Soluble Nutrients appears later in this issue.


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