What Doctors Don't Know about Inflammation
By Logan Bronwell
Colitis and Gastro-Protection
Colitis—meaning inflammation of the colon, or large intestine—is most commonly seen in inflammatory bowel disease, including Crohn's disease. The Centers for Disease Control estimates that up to 1.4 million Americans suffer from this condition.27
There is still no medical cure.
However, black cumin seed oil and its components exert powerful effects that can slow colonic inflammation.6 Lab studies reveal that pre-treating animals with thymoquinone as extracted from black cumin seed oil completely prevents experimentally-induced colitis.28
Importantly, treatment with black cumin seed oil lowers levels of pro-inflammatory cytokines.29
Studies have shown that both black cumin seed oil and thymoquinone strongly protect the delicate stomach lining against the injurious effects of alcohol and other toxins, and even against the effects of stress.30,31 Markers of tissue oxidation were sharply reduced.30
Atherosclerosis is a major consequence of chronic inflammation—making it an appropriate target for therapy with anti-inflammatory black cumin seed oil, with its powerful antioxidant effects. Working together, these two mechanisms lower the risk of atherosclerosis and consequently, heart attacks, strokes, and other artery diseases.
Animals supplemented with black cumin seed oil demonstrated lower levels of dangerous LDL-cholesterol, and higher levels of HDL cholesterol, which may be protective.32,33
Black cumin seed oil neutralizes lipid oxidation and reduces the impact of oxidized LDL, a major trigger for the atherosclerotic plaques that block blood flow to cause heart attacks and strokes.33
Black cumin seed oil has a major impact on a destructive process known as ischemia-reperfusion injury. This serious damage occurs to tissue and organs when, following blockage of an artery, the oxygen-rich blood flow is then restored. This complex phenomenon releases a massive outpouring of reactive oxygen species that can damage tissue as severely as the original blockage! Ischemia-reperfusion injury is responsible for many of the debilitating long-term effects seen in survivors of strokes and heart attacks.
For example, the powerful protection provided by black cumin seed oil against ischemia-reperfusion injury has now been convincingly demonstrated in the kidney—one of the main targets of the insidious effects of atherosclerosis.34
The twin problems of increased harmful chronic inflammation combined with decreased beneficial immune responses are major contributors to aging, chronic disease, and early death.
The oil of black cumin seed has historically been used to combat conditions we now understand to be related to these fundamental, age-related, inflammatory and immunological disturbances.
Modern scientific analysis shows that black cumin seed oil contains components that re-establish optimal inflammatory balance—powerfully suppressing chronic inflammation, while at the same time promoting healthy immune responses.
As a result of that delicate immunological balancing, supplementation with black cumin seed oil has the potential to slow—and even reverse—many of the most devastating aging-related conditions.
If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.
1. Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan;8(1):18-30.
2. Jenny NS, French B, Arnold AM, et al. Long-term assessment of inflammation and healthy aging in late life: The Cardiovascular Health Study All Stars. J Gerontol A Biol Sci Med Sci. 2012 Feb 24. [Epub ahead of print]
3. Franceschi C. Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev. 2007 Dec;65(12 Pt 2):S173-6.
4. Kanapeckiene V, Kalibatas J, Redaitiene E, Ceremnych J. The association between cytomegalovirus infection and aging process. Medicina (Kaunas). 2007;43(5):419-24.
5. Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6(b):495-510.
6. Shahzad M, Yang X, Raza Asim MB, et al. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther. 2009 Feb;22(1):37-43. Epub 2008 Nov 27.
7. Butt MS, Sultan MT. Nigella sativa: reduces the risk of various maladies. Crit Rev Food Sci Nutr. 2010 Aug;50(7):654-65.
8. Finlay TM, Abdulkhalek S, Gilmour A, et al. Thymoquinone-induced Neu4 sialidase activates NFkappaB in macrophage cells and pro-inflammatory cytokines in vivo. Glycoconj J. 2010 Aug;27(6):583-600.
9. Finlay TM, Jayanth P, Amith SR, et al. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J. 2010 Apr;27(3):329-48.
10. Majdalawieh AF, Hmaidan R, Carr RI. Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity. J Ethnopharmacol. 2010 Sep 15;131(2):268-75. Epub 2010 Jun 30.
11. Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol. 2000 Sep;22(9):729-40.
12. Salem ML, Alenzi FQ, Attia WY. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro. Br J Biomed Sci. 2011;68(3):131-7.
13. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005 Dec;5(13-14):1749-70.
14. Available at: http://www.sciencedaily.com/releases/2011/04/110419091159.htm. Accessed August 2, 2012.
15. Chen WP, Tang JL, Bao JP, Wu LD. Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis. Exp Biol Med (Maywood). 2010 Dec;235(12):1425-31.
16. Available at: http://www.cdc.gov/nchs/fastats/arthrits.htm. Accessed July 12, 2012.
17. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa Oil in the Management of Rheumatoid Arthritis Patients: A Placebo Controlled Study. Phytother Res. 2011 Dec 12.
18. Available at: http://www.cdc.gov/Features/dsArthritis/. Accessed July 12, 2012.
19. Available at: http://www.cdc.gov/nchs/fastats/allergies.htm. Accessed July 12, 2012.
20. Available at: http://www.cdc.gov/nchs/fastats/asthma.htm . Accessed July 12, 2012.
21. Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA. Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem Biol Interact. 2012 Apr 15;197(1):40-6.
22. Abbas AT, Abdel-Aziz MM, Zalata KR, Abd Al-Galel Tel D. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol. 2005;12(1):95-102.
23. Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N. Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol. 2011 Sep-Oct;32(5):402-7.
24. Al-Majed AA, Daba MH, Asiri YA, Al-Shabanah OA, Mostafa AA, El-Kashef HA. Thymoquinone-induced relaxation of guinea-pig isolated trachea. Res Commun Mol Pathol Pharmacol. 2001;110(5-6):333-45.
25. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol. 2006 Jul;6(7):1135-42.
26. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC. Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta. 2006 Jul;1760(7):1088-95.
27. Available at: http://www.cdc.gov/ibd/. Accessed July 12, 2012.
28. Mahgoub AA. Thymoquinone protects against experimental colitis in rats. Toxicol Lett. 2003 Jul 20;143(2):133-43.
29. Isik F, Tunali Akbay T, Yarat A, et al. Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats. Dig Dis Sci. 2011 Mar;56(3):721-30.
30. Kanter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol. 2005 Nov 14;11(42):6662-6.
31. Abdel-Sater KA. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol. 2009;1(2):143-49.
32. Al-Naqeep G, Al-Zubairi AS, Ismail M, Amom ZH, Esa NM. Antiatherogenic potential of Nigella sativa seeds and oil in diet-induced hypercholesterolemia in rabbits. Evid Based Complement Alternat Med. 2011;2011:213628.
33. Nader MA, el-Agamy DS, Suddek GM. Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharm Res. 2010 Apr;33(4):637-43. Epub 2010 Apr 27.
34. Bayrak O, Bavbek N, Karatas OF, et al. Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys. Nephrol Dial Transplant. 2008 Jul;23(7):2206-12.
35. Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012 Feb 15;83(4):443-51.
36. Sethi G, Ahn KS, Aggarwal BB. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res. 2008 Jun;6(6):1059-70.
37. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995 Feb;61(1):33-6.
38. Mansour M, Tornhamre S. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. J Enzyme Inhib Med Chem. 2004 Oct;19(5):431-6.
39. El-Dakhakhny M, Madi NJ, Lembert N, Ammon HP. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J Ethnopharmacol. 2002 Jul;81(2):161-4.
40. Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M. Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J Cell Biochem. 2011 Jan;112(1):107-17.
41. Keyhanmanesh R, Boskabady MH, Khamneh S, Doostar Y. Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs. Pharmacol Rep. 2010 Sep-Oct;62(5):910-6.
42. Nemmar A, Al-Salam S, Zia S, et al. Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone. Br J Pharmacol. 2011 Dec;164(7):1871-82.