Circumvent Today’s Leading Cause of DeathSeptember 2013
By William Faloon
Keeping the Blood Flowing
Atherosclerosis is the most deadly disease in the United States, yet most doctors still do not understand how it develops. While most people think of their arteries becoming clogged like a pipe, the fact is that the aging process damages the inner linings of blood vessels, even when conventional risk factors such as cholesterol and blood pressure are within normal ranges.25
While high cholesterol levels contribute to atherosclerosis, the mechanism by which it most damages the arterial wall is quite different than what drug companies promote. When levels of cholesterol (and other atherogenic risk factors) are too high, there is a corresponding reduction in the amount of nitric oxide available to the endothelial lining of the arteries.26
Nitric oxide is a critically needed substance that enables the arteries to expand and relax with youthful elasticity.27 The encouraging news is that novel approaches are available that have been shown to safely increase nitric oxide and reverse atherosclerosis markers in humans and animals.28-33
In the 2014 edition of Disease Prevention and Treatment, readers will learn how to circumvent the many overlooked factors that make aging humans so vulnerable to artery disease and subsequent stroke and heart attack.
Protect Healthy Tissues Against Lethal Radiation Damage
Even if cancer is completely cured by radiation therapy, there is sometimes severe peripheral damage to healthy tissues known as radiation fibrosis.34 Life Extension long ago advised those undergoing radiation to use a drug-nutrient combination that was shown to promote healing time and reduce pain following radiation damage.
A more dangerous form of radiation damage, however, occurs when treating cancers involving the brain. The high levels of radiation used to treat tumors in the brain can result in a lethal side effect called radiation necrosis that manifests long after the therapy is discontinued.35-37
The swelling of the brain caused by radiation necrosis can lead to dementia or death.38,39 Doctors treat the brain swelling by administering anti-inflammatory steroid drugs. At some point, steroid drug therapy fails. Years ago, one expert complained that no matter how many brain tumors are cured with radiation therapy, the patients eventually died from radiation necrosis.
What conventional doctors overlook is that even when brain swelling is temporarily controlled, the radiation necrosis process itself continues to stimulate inflammatory cytokines. The result is a vicious cycle where damaged brain tissues keep provoking inflammatory cytokines that cause even more necrotic damage, which then promotes even more inflammatory cytokine production (and more necrotic damage).
In the 2014 edition of Disease Prevention and Treatment, a breakthrough drug-nutrient cocktail is introduced to suppress the chronic inflammatory-cytokine cascade and gain long-term control over radiation necrosis.
Why You’ll Want This Book in Your Library or on Your Coffee Table
For the past 33 years, Life Extension has published life-saving information a decade or more ahead of conventional medicine. A case-in-point is Life Extension’s advice to take low-dose aspirin to prevent heart attacks. While mainstream hospitals like Johns Hopkins now advocate aspirin to prevent heart attacks, the Life Extension Foundation® published evidence about aspirin’s benefits back in 1983. The Life Extension Foundation® then spent 15 years battling the FDA to force the agency to recognize the cardio-protective effects of low-dose aspirin.
When a serious medical disorder develops, most people have no one to turn to other than their doctor. The problem is that physicians are often too busy to keep up with the latest research findings. As a result, many patients suffer and die even though advanced therapies already exist that could cure them.
For example, in 2005 “Tamiflu®” became a household word as fears of an avian flu epidemic caused a shortage of this anti-viral drug. Those who purchased the year 2003 edition of Disease Prevention and Treatment, however, learned about Tamiflu before the public and were advised about the benefits of having it available to prevent a flu virus infection.
A stark illustration of the failure of doctors to recognize the value of life-saving medical breakthroughs was a study showing that the drug cimetidine improved survival odds in a group of colon cancer patients.40 In this landmark study, patients with an aggressive form of colon cancer took 800 mg of cimetidine for one year after surgery. After ten years, there was nearly a 60% improvement in survival in the group that took cimetidine.
As early as 1985, the Life Extension Foundation recommended cimetidine as an adjuvant cancer therapy. If you had been a Life Extension member and contracted colon cancer, your odds of dying could have been reduced dramatically.
Many colon cancer patients learned about the enormous value of cimetidine in the year 2003 edition ofDisease Prevention and Treatment. The brand new 2014 edition of Disease Prevention and Treatment provides even more novel therapies for colon cancer patients to consider.
For those afflicted with chronic illnesses, the new information contained in the 2014 edition of Disease Prevention and Treatment could result in a liberating experience. When a medical concern arises, you don’t want to be left in the darkness of scientific ignorance.
By keeping the latest edition of Disease Prevention and Treatment close by, you will quickly be able to use the expanded index to educate yourself about novel therapies that have shown efficacy in peer-reviewed studies, but have not yet made it into conventional medical practice.
Save Over 60% on Disease Prevention and Treatment
Life Extension has spent millions of dollars in researching, writing, and editing the 130 chapters that comprise the 2014 edition of Disease Prevention and Treatment. We expect to recoup some of this expenditure when we release it to book stores in January 2014.
We want every one of our members to have this updated reference book in their homes today. To encourage this, we are offering the book to members at a 64% discount off the cover price of Disease Prevention and Treatment until January 31, 2014.
This beautiful hardbound book retails for $69.95…a far lower price than what medical textbooks like this normally cost. Until January 31, 2014, you can obtain the 2014 edition of Disease Prevention and Treatment for only $24.95.
To order your personal copy of the new Disease Prevention and Treatment reference book, call 1-800-544-4440 today.
If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.
- Available at: http://jama.jamanetwork.com/article.aspx?articleid=1667095. Accessed May 17, 2013.
- Available at: http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0040256. Accessed May 9, 2013.
- Available at: http://www.yale.edu/macmillan/apartheid/nattrassp2.pdf. Accessed May 9, 2013.
- Available at: http://www.africa.upenn.edu/Articles_Gen/aids_afr.html. Accessed June 6, 2013.
- Available at: http://www.who.int/water_sanitation_health/publications/factsfigures04/en/. Accessed May 17, 2013.
- Available at: http://www.webmd.com/a-to-z-guides/cholera-faq. Accessed May 9, 2013.
- Middleton MH, Nazarenko G, Nivison-Smith I, Smerdely P. Prevalence of malnutrition and 12-month incidence of mortality in two Sydney teaching hospitals. Intern Med J. 2001 Nov;31(8):455-61.
- Barker LA, Gout BS, Crowe TC. Hospital malnutrition: prevalence, identification and impact on patients and the healthcare system. Int J Environ Res Public Health. 2011 Feb;8(2):514-27.
- Kyle UG, Genton L, Pichard C. Hospital length of stay and nutritional status. Curr Opin Clin Nutr Metab Care. 2005 Jul;8(4):397-402.
- Available at: http://www.nature.com/ejcn/journal/v57/n7/full/1601616a.html. Accessed May 9, 2013.
- Holyday M, Daniells S, Bare M, Caplan GA, Petocz P, Bolin T. Malnutrition screening and early nutrition intervention in hospitalised patients in acute aged care: a randomised controlled trial. J Nutr Health Aging. 2012;16(6):562-8.
- Michalek RD, Rathmell JC. The metabolic life and times of a T-cell. Immunol Rev. 2010 Jul;236:190-202.
- Fritz V, Fajas L. Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene. 2010 Aug 5;29(31):4369-77.
- Lloyd-Jones et al. Heart disease and stroke statistics—2010 Update. Circulation. 2010 Feb 23;121(7):e46-e215.
- Lloyd-jones et al. Hypertension in adults across the age spectrum. JAMA. 2005 Jul 27;294(4):466-72.
- Roger VL. Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation. 2011 Feb 1;123(4):e18-e209.
- Jeckel CM, Lopes RP, Berleze MC, et al. Neuroendocrine and immunological correlates of chronic stress in ‘strictly healthy’ populations. Neuroimmunomodulation. 2010;17(1):9-18
- Wolkowitz OM, Reus VI, Keebler A, et al. Double-blind treatment of major depression with dehydroepiandosterone. Am J Psychiatry. 1999 Apr;156(4):646-9.
- Wolkowitz OM, Reus VI, Manfredi F, et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry. 1997 Feb 1;41(3):311-8.
- Craelius W. comparative epidemiology of multiple sclerosis and dental caries. J Epidemiol Community Health. 1978 Sep;32(3):155-65.
- Goldberg P. Multiple Sclerosis: vitamin D and calcium as environmental determinants of prevalence (a viewpoint). Part 1: sunlight, dietary factors and epidemiology. Intern J Environ Stud. 1974, 6: 19-27.
- Burton JM, Kimball S, Vieth R, et al. A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. Neurology. 2010 Jun 8;74(23):1852-9.
- Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol. 2008 Aug;4(8):404-12.
- Soilu-Hänninen M, Laaksonen M, Laitinen I, Erälinna JP, Lilius EM, Mononen I. A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008 Feb;79(2):152-7.
- Available at: http://www.nia.nih.gov/health/publication/aging-hearts-and-arteries-scientific-quest/chapter-4-blood-vessels-and-aging-rest. Accessed May 9, 2013.
- Gattullo D, Pagliaro P, Marsh NA, Losano G. New insights into nitric oxide and coronary circulation. Life Sci. 1999;65(21):2167-74.
- Sugawara J, Komine H, Hayashi K, et al. Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans. Hypertens Res. 2007 May;30(5):411-5.
- Cloarec M, Caillard P, Provost JC, Dever JM, Elbeze Y, Zamaria N. GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging. Allerg Immunol.(Paris). 2007 Feb;39(2):45-50.
- de Nigris F, Williams-Ignarro S, Lerman LO, et al. Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress. Proc Natl Acad Sci USA. 2005 Mar 29;102(13):4896-901.
- Sies H, Schewe T, Heiss C, et al. Cocoa polyphenols and inflammatory mediators. Am J Clin Nutr. 2005a Jan;81(1 Suppl):304S-312S.
- Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005 Mar;81(3):611-4.
- Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33.
- Kaplan M, Hayek T, Raz A, et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr. 2001 Aug;131(8):2082-9.
- Burger A, Löffler H, Bamberg M, Rodemann HP. Molecular and cellular basis of radiation fibrosis. Int J Radiat Biol. 1998 73(4):401-8.
- Available at: http://emedicine.medscape.com/article/1157533-overview. Accessed May 9, 2013.
- Plimpton SR, Stence N, Hemenway M, Hankinson TC, Foreman N, Liu AK. Cerebral Radiation Necrosis in Pediatric Patients. Pediatr Hematol Oncol. 2013 May 7. [Epub ahead of print]
- DeAngelis LM, Delattre JY, Posner JB. Radiation-induced dementia in patients cured of brain metastases. Neurology. 1989 Jun;39(6):789-96.
- Crossen JR, Garwood D, Glatstein E, Neuwelt EA. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol. 1994 Mar;12(3):627-42.
- Johannesen TB, Lien HH, Hole KH, Lote K. Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy. Radiother Oncol. 2003 Nov;69(2):169-76.
- Matsumoto S, Imaeda Y, Umemoto S, Kobayashi K, Suzuki H, Okamoto T. Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. Br J Cancer. 2002 Jan 21;86(2):161-7.