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Studies from Brigham and Women's Hospital Provide New Data on Heart Failure


By a News Reporter-Staff News Editor at Blood Weekly -- Investigators publish new report on Heart Diseases and Conditions. According to news reporting originating in Boston, Massachusetts, by NewsRx journalists, research stated, "Aim To examine the association of plasma fatty acid-binding protein 4 (FABP4) with incident heart failure. In a prospective study of 4179 participants from the Cardiovascular Health Study, we measured plasma FABP4 on blood specimens collected between 1992 and 1993."

The news reporters obtained a quote from the research from Brigham and Women's Hospital, "Incident heart failure was adjudicated by an endpoint committee and we used a Cox proportional hazards model to calculate hazard ratios (HRs) of heart failure. The average age at baseline was 75 years. During a median follow-up of 10.7 years, 1182 cases of incident heart failure occurred. We observed a positive association between FABP4 and heart failure in the minimally adjusted models [HR 1.32, 95% confidence interval (CI) 1.25-1.38 per 1 SD higher FABP4] that was attenuated upon adjustment for potential confounders, mostly kidney function and body mass index (corresponding HR 1.09, 95% CI 1.01-1.17). In a subsample of heart failure cases with available data on LV systolic function, FABP4 was not associated with heart failure with or without preserved LV systolic function. Exclusion of people with unintentional weight loss and self-reported fair/poor health status did not alter the conclusion."

According to the news reporters, the research concluded: "An elevated plasma concentration of FABP4 was associated with a modestly higher risk of heart failure in older adults in the USA after adjustment for confounding factors."

For more information on this research see: Fatty acid-binding protein 4 and incident heart failure: the Cardiovascular Health Study. European Journal of Heart Failure, 2013;15(4):394-9. (Oxford University Press -; European Journal of Heart Failure -

Our news correspondents report that additional information may be obtained by contacting L. Djousse, Division of Aging, Dept. of Medicine, Brigham and Women's Hospital and Harvard Medical School and Boston Veterans Affairs Healthcare System, Boston, MA, United States (see also Heart Diseases and Conditions).

Keywords for this news article include: Boston, Cardiology, Massachusetts, United States, Heart Failure, Carrier Proteins, Risk and Prevention, Cardiovascular Diseases, North and Central America, Fatty Acid Binding Proteins, Heart Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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