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Researchers from Washington University Report Recent Findings in Spinal Research


By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Spinal Research. According to news reporting originating from St. Louis, Missouri, by NewsRx correspondents, research stated, "Retrospective investigation of cross-sectional data. To define the prevalence and determinants of preoperative vitamin D deficiency among adults undergoing spinal fusion."

Our news editors obtained a quote from the research from Washington University, "Summary of Background Data. Vitamin D plays a critical role in establishing optimal bone health, which, in turn, is vital to the success of spinal arthrodesis. Recently, hypovitaminosis D was documented in 43% of adults undergoing any orthopedic surgery. Serum 25-hydroxyvitamin D levels were routinely measured in adults undergoing spinal fusion at a single institution. Between January 2010 and March 2011, 313 patients were retrospectively identified for inclusion. Risk factors for vitamin D deficiency (<20 ng/mL) were analyzed using univariate analysis and multivariate logistic regression. The rates of inadequacy (<30 ng/mL) and deficiency were 57% and 27%, respectively. Although 260 patients were diagnosed with degenerative disease (spondylosis), 99 had deformity, and there were 73 revision cases. There was a higher rate of smoking (P = 0.03) and lower age (P < 0.01) in the vitamin D-deficient subset. There was no sex difference. Increasing body mass index (P < 0.01), increasing Neck and Oswestry Disability Index scores (P = 0.03), and lack of vitamin D and/or multivitamin supplementation (P < 0.01) remained predictors of deficiency after multivariate analysis. Those with previous supplementation were older (P < 0.01) and more likely to be at least 50 years old than those without repletion (P < 0.01). Our investigation revealed a substantially high prevalence of vitamin D abnormality in the analyzed population. Although advanced age is a well-established risk factor for hypovitaminosis, young adults undergoing fusion should not be overlooked with regard to vitamin D screening; this age bracket is less likely to have been previously supplemented."

According to the news editors, the research concluded: "In the absence of better-recognized determinants, spinal disability indices may also be useful in identifying those with deficiency."

For more information on this research see: Preoperative Vitamin D Status of Adults Undergoing Surgical Spinal Fusion. SPINE, 2013;38(6):507-515. SPINE can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins -; SPINE -

The news editors report that additional information may be obtained by contacting G.E. Stoker, Washington University, Dept. of Orthopaed Surg, St Louis, MO 63110, United States (see also Spinal Research).

Keywords for this news article include: Missouri, St. Louis, United States, Spinal Research, North and Central America

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