Researchers from State University of New York Detail Findings in Carcinogenesis
By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Carcinogenesis are discussed in a new report. According to news reporting originating from Rensselaer, New York, by NewsRx editors, the research stated, "Epidemiologic data suggest that the incidence and severity of many types of cancer inversely correlates with indices of vitamin D status. The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis."
Our news editors obtained a quote from the research from the State University of New York, "Consistent with this concept, activation of VDR by its ligand 1,25-dihydroxyvitamin D (1,25D) triggers comprehensive genomic changes in epithelial cells that contribute to maintenance of the differentiated phenotype, resistance to cellular stresses and protection of the genome. Many epithelial cells also express the vitamin D metabolizing enzyme CYP27B1 which enables autocrine generation of 1,25D from the circulating vitamin D metabolite 25-hydroxyvitamin D (25D), critically linking overall vitamin D status with cellular anti-tumor actions. Furthermore, pre-clinical studies in animal models has demonstrated that dietary supplementation with vitamin D or chronic treatment with VDR agonists decreases tumor development in skin, colon, prostate and breast. Conversely, deletion of the VDR gene in mice alters the balance between proliferation and apoptosis, increases oxidative DNA damage, and enhances susceptibility to carcinogenesis in these tissues. Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer."
According to the news editors, the research concluded: "Collectively, these observations have reinforced the need to further define the molecular actions of the VDR and the human requirement for vitamin D in relation to cancer development and progression."
For more information on this research see: Cellular and molecular effects of vitamin D on carcinogenesis. Archives of Biochemistry and Biophysics, 2012;523(1):107-14. (Elsevier - www.elsevier.com; Archives of Biochemistry and Biophysics - www.elsevier.com/wps/product/cws_home/622787)
The news editors report that additional information may be obtained by contacting J. Welsh, Cancer Research Center, University at Albany, Rensselaer, NY 12144, United States (see also Carcinogenesis).
Keywords for this news article include: Cancer, New York, Genetics, Oncology, Rensselaer, United States, Carcinogenesis, Epithelial Cells, North and Central America.
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