Studies from University of Naples Federico II Update Current Data on Hepatitis C Virus
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Liver Diseases and Conditions have been published. According to news reporting originating in Naples, Italy, by NewsRx journalists, research stated, "In vitro, vitamin B-12 acts as a natural inhibitor of hepatitis C virus (HCV) replication. To assess the effect of vitamin B-12 on virological response in patients with chronic HCV hepatitis naive to antiviral therapy."
The news reporters obtained a quote from the research from the University of Naples Federico II, "Ninety-four patients with chronic HCV hepatitis were randomly assigned to receive pegylated interferon alpha plus ribavirin (standard-of-care; SOC) or SOC plus vitamin B-12 (SOC+B-12). Viral response-namely, undetectable serum HCV-RNA, was evaluated 4 weeks after starting treatment (rapid viral response), 12 weeks after starting treatment (complete early viral response) and 24 or 48 weeks after starting treatment (end-of-treatment viral response) and 24 weeks after completing treatment (sustained viral response (SVR)). Genotyping for the interleukin (IL)-28B polymorphism was performed a posteriori in a subset (42/64) of HCV genotype 1 carriers. Overall, rapid viral response did not differ between the two groups, whereas the rates of complete early viral response (p=0.03), end-of-treatment viral response (p=0.03) and SVR (p=0.001) were significantly higher in SOC+B-12 patients than in SOC patients. In SOC+B-12 patients, the SVR rate was also significantly higher in carriers of a difficult-to-treat genotype (p=0.002) and in patients with a high baseline viral load (p=0.002). Distribution of genotype IL-28B did not differ between the two groups. At multivariate analysis, only easy-to-treat HCV genotypes (OR=9.00; 95% CI 2.5 to 37.5; p=0.001) and vitamin B-12 supplementation (OR=6.9; 95% CI 2.0 to 23.6; p=0.002) were independently associated with SVR."
According to the news reporters, the research concluded: "Vitamin B-12 supplementation significantly improves SVR rates in HCV-infected patients naive to antiviral therapy."
For more information on this research see: Vitamin B-12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus. Gut, 2013;62(5):766-773. Gut can be contacted at: Bmj Publishing Group, British Med Assoc House, Tavistock Square, London WC1H 9JR, England. (BMJ Publishing Group - group.bmj.com/; Gut - gut.bmj.com/)
Our news correspondents report that additional information may be obtained by contacting A. Rocco, University of Naples Federico II, Internal Med Unit, I-80131 Naples, Italy (see also Liver Diseases and Conditions).
Keywords for this news article include: HCV, Italy, Viral, Naples, Europe, Genetics, Virology, Hepatology, RNA Viruses, Gastroenterology, Hepatitis C Virus, Infectious Disease, Flaviviridae Infections, Digestive System Diseases, Liver Diseases and Conditions
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