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Recent Findings from Research Foundation Provide New Insights into Gastroenterology


By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Gastroenterology have been published. According to news reporting from Westminster, California, by NewsRx journalists, research stated, "Primary biliary cirrhosis (PBC) is an immune-mediated chronic inflammatory disease of the liver of unknown etiology. Vitamin D deficiency is highly prevalent in patients with PBC, and many studies have demonstrated the significant effect of calcitriol on liver cell physiology."

The news correspondents obtained a quote from the research from Research Foundation, "Vitamin D has antiproliferative and antifibrotic effects on liver fibrosis. Genetic studies have provided an opportunity to determine which proteins link vitamin D to PBC pathology (e.g., the major histocompatibility complex class II molecules, the vitamin D receptor, toll-like receptors, apolipoprotein E, Nramp1, and cytotoxic T lymphocyte antigen-4). Vitamin D also exerts its effect on PBC through cell signaling mechanisms, that is, matrix metalloproteinases, prostaglandins, reactive oxygen species, and the transforming growth factor betas."

According to the news reporters, the research concluded: "Vitamin D may have a beneficial role in the treatment of PBC. The best form of vitamin D for use in the PBC is calcitriol because it is the active form of vitamin D3 metabolite, and its receptors are present in the sinusoidal endothelial cells, Kupffer cells, and stellate cells of normal livers, as well as in the biliary cell line."

For more information on this research see: The role of vitamin d in primary biliary cirrhosis: possible genetic and cell signaling mechanisms. Gastroenterology Research and Practice, 2013;2013():602321. (Hindawi Publishing -; Gastroenterology Research and Practice -

Our news journalists report that additional information may be obtained by contacting K.V. L Ng, Vietnamese American Medical Research Foundation, 14971 Brookhurst Street, Westminster, CA 92683, United States (see also Gastroenterology).

Keywords for this news article include: Fibrosis, Genetics, California, Hepatology, Westminster, United States, Gastroenterology, Biliary Cirrhosis, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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