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Researchers at University of Alabama Report New Data on Heart Disease


By a News Reporter-Staff News Editor at Heart Disease Weekly -- Researchers detail new data in Heart Disease. According to news reporting from Birmingham, Alabama, by NewsRx journalists, research stated, "Obesity is associated with elevated risk of heart disease. A solid understanding of the safety and potential adverse effects of high-fat, low-carbohydrate diet (HFLCD) similar to that used by humans for weight loss on the heart is crucial."

The news correspondents obtained a quote from the research from the University of Alabama, "High fat intake is known to promote increases in reactive oxygen species and mitochondrial damage. We hypothesized that there would be adverse effects of HFLCD on myocardial ischemia/reperfusion injury through enhancing oxidative stress injury and impairing mitochondrial biogenesis in a nongenetic, diet-induced rat model of obesity. To test the hypothesis, 250-g male Sprague-Dawley rats were fed an obesity-promoting diet for 7 weeks to induce obesity, then switched to HFLCD or a low-fat control diet for 2 weeks. Isolated hearts underwent global low flow ischemia for 60 minutes and reperfusion for 60 minutes. High-fat, low-carbohydrate diet resulted in greater weight gain and lower myocardial glycogen, plasma adiponectin, and insulin. Myocardial antioxidant gene transcript and protein expression of superoxide dismutase and catalase were reduced in HFLCD, along with increased oxidative gene NADPH oxidase-4 transcript and xanthine oxidase activity, and a 37% increase in nitrated protein (nitrotyrosine) in HFLCD hearts. The cardiac expression of key mitochondrial regulatory factors such as nuclear respiratory factor-1 and transcription factor A-mitochondrial were inhibited and myocardial mitochondrial DNA copy number decreased. The cardiac expression of adiponectin and its receptors was down-regulated in HFLCD. High-fat, low-carbohydrate diet impaired recovery of left ventricular rate-pressure product after ischemia/reperfusion and led to 3.5-fold increased injury as measured by lactate dehydrogenase release."

According to the news reporters, the research concluded: "HFLCD leads to increased ischemic myocardial injury and impaired recovery of function after reperfusion and was associated with attenuation of mitochondrial biogenesis and enhanced oxidative stress in obese rats. These findings may have important implications for diet selection in obese patients with ischemic heart disease."

For more information on this research see: High-fat, low-carbohydrate diet alters myocardial oxidative stress and impairs recovery of cardiac function after ischemia and reperfusion in obese rats. Nutrition Research, 2013;33(4):311-21. (Elsevier -; Nutrition Research -

Our news journalists report that additional information may be obtained by contacting J. Liu, Dept. of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, United States (see also Heart Disease).

Keywords for this news article include: Alabama, Obesity, Ischemia, Birmingham, Bariatrics, Cardiology, United States, Heart Disease, Overnutrition, Diet and Nutrition, Nutrition Disorders, Risk and Prevention, North and Central America, Constrictive Pericarditis.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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