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Investigators at University of Joseph Fourier Zero in on Alzheimer Disease and Other Dementias


By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Alzheimer Disease and Other Dementias have been published. According to news reporting originating from Grenoble, France, by NewsRx correspondents, research stated, "Seasonal or chronic vitamin D deficiency and/or insufficiency is highly prevalent in the human population. Receptors for 1,25-dihydroxyvitamin D3, the hormonal metabolite of vitamin D, are found throughout the brain."

Our news editors obtained a quote from the research from the University of Joseph Fourier, "To provide further information on the role of this hormone on brain function, we analyzed the transcriptomic profiles of mixed neuron-glial cell cultures in response to 1,25-dihydroxyvitamin D3. 1,25-dihydroxyvitamin D3 treatment increases the mRNA levels of 27 genes by at least 1.9 fold. Among them, 17 genes were related to neurodegenerative and psychiatric diseases, or brain morphogenesis. Notably, 10 of these genes encode proteins potentially limiting the progression of Alzheimer's disease. These data provide support for a role of 1,25-dihydroxyvitamin D3 in brain disease prevention."

According to the news editors, the research concluded: "The possible consequences of circannual or chronic vitamin D insufficiencies on a tissue with a low regenerative potential such as the brain should be considered."

For more information on this research see: The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases. Journal of Alzheimer's Disease, 2013;35(3):553-64. Journal of Alzheimer's Disease can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands (see also Alzheimer Disease and Other Dementias).

The news editors report that additional information may be obtained by contacting M.F. Nissou, INSERM U836, Batiment Edmond J Safra, Universite Joseph Fourier, CHU Michallon, Grenoble, France.

Publisher contact information for the Journal of Alzheimer's Disease is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.

Keywords for this news article include: Cells, France, Europe, Neurons, Grenoble, Nervous System Diseases, Neurodegenerative Diseases, Alzheimer Disease and Other Dementias.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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