University of Illinois Reports Findings in Prostate Cancer
By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Research findings on Prostate Cancer are discussed in a new report. According to news reporting originating from Chicago, Illinois, by NewsRx correspondents, research stated, "Clinical trials and animal studies have suggested that lycopene, the red carotenoid found in tomatoes, might be useful for the prevention of prostate cancer in the diet or as a dietary supplement through a variety of chemoprevention mechanisms. As most mechanism of action studies have used prostate cancer cells or males with existing prostate cancer, we investigated the effects of lycopene on protein expression in human primary prostatic epithelial cells."
Our news editors obtained a quote from the research from the University of Illinois, "After treatment with lycopene at a physiologically relevant concentration (2 mu mol/L) or placebo for 48 hours, the primary prostatic epithelial cells were lysed and fractionated using centrifugation into cytosolic/membrane and nuclear fractions. Proteins from lycopene-treated and placebo-treated cells were trypsinized and derivatized for quantitative proteomics using isobaric tags for relative and absolute quantitation (iTRAQ) reagent. Peptides were analyzed using two-dimensional microcapillary high-performance liquid chromatography-tandem mass spectrometry to identify proteins that were significantly upregulated or downregulated following lycopene exposure. Proteins that were most affected by lycopene were those involved in antioxidant responses, cytoprotection, apoptosis, growth inhibition, androgen receptor signaling, and the Akt/mTOR cascade."
According to the news editors, the research concluded: "These data are consistent with previous studies suggesting that lycopene can prevent cancer in human prostatic epithelial cells at the stages of cancer initiation, promotion, and/or progression."
For more information on this research see: Effects of Lycopene on Protein Expression in Human Primary Prostatic Epithelial Cells. Cancer Prevention Research, 2013;6(5):419-427. Cancer Prevention Research can be contacted at: Amer Assoc Cancer Research, 615 Chestnut St, 17TH Floor, Philadelphia, PA 19106-4404, USA. (American Association for Cancer Research - www.aacr.com; Cancer Prevention Research - cancerpreventionresearch.aacrjournals.org/)
The news editors report that additional information may be obtained by contacting X. Qiu, University of Illinois, Coll Pharm, Dept. of Pathol, Chicago, IL 60612, United States (see also Prostate Cancer).
Keywords for this news article include: Chicago, Illinois, Oncology, Peptides, Proteomics, Amino Acids, United States, Epithelial Cells, Protein Expression, Prostatic Neoplasms, Risk and Prevention, North and Central America, Metastatic Prostate Cancer, Clinical Trials and Studies
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