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Findings from Danbury Hospital in the Area of Takotsubo Cardiomyopathy Described


By a News Reporter-Staff News Editor at Clinical Trials Week -- Data detailed on Heart Diseases and Conditions have been presented. According to news reporting from Danbury, Connecticut, by NewsRx journalists, research stated, "The purpose of this study was to identify the prevalence and clinical consequences of vitamin D insufficiency in patients with takotsubo cardiomyopathy. Takotsubo cardiomyopathy is a syndrome of acute, transient left ventricular dysfunction seen predominantly in postmenopausal women after acute emotional or physical stress."

The news correspondents obtained a quote from the research from Danbury Hospital, "Postmenopausal women have a high prevalence of bone and musculoskeletal consequences related to hypovitaminosis D. Although rickets is known to cause a reversible dilated cardiomyopathy in children, the importance of vitamin D for adult cardiovascular health is less understood. We prospectively identified patients diagnosed with takotsubo cardiomyopathy at Danbury Hospital from April 2009 through January 2011, collected demographic, clinical, laboratory, and angiographic data, and performed serum 25 hydroxyvitamin D levels during the index hospitalization. Vitamin D insufficiency was defined as serum 25-hydroxy-vitamin D less than 30 ng/mL. We compared parameters of myocardial damage and heart failure between patients with and without vitamin D insufficiency. A chi(2) test and a Student's t test were used for categorical and continuous variables, respectively. Statistical significance was set at P< .05 (2 tailed). Twenty-seven women were diagnosed with takotsubo cardiomyopathy during the study period. The mean age was 67.4 years (SD 10.4). The serum 25-hydroxyvitamin D levels were performed on 25 patients, and 17 of these had hypovitaminosis D (68%). A comparison of laboratory and imaging parameters between the 2 groups revealed that patients with hypovitaminosis D had a slightly higher mean left ventricular end-diastolic pressure and lower mean left ventricular ejection fraction (P < .05), suggestive of slightly worse heart failure. Women diagnosed with takotsubo cardiomyopathy have a high prevalence of vitamin D insufficiency."

According to the news reporters, the research concluded: "In our prospective study of 25 women with takotsubo cardiomyopathy, this was associated with worse hemodynamic parameters."

For more information on this research see: Prevalence and Consequences of Vitamin D Insufficiency in Women With Takotsubo Cardiomyopathy. Journal of Clinical Endocrinology & Metabolism, 2013;98(5):E872-E876. Journal of Clinical Endocrinology & Metabolism can be contacted at: Endocrine Soc, 8401 Connecticut Ave, Suite 900, Chevy Chase, MD 20815-5817, USA. (The Endocrine Society -; Journal of Clinical Endocrinology & Metabolism -

Our news journalists report that additional information may be obtained by contacting A.S. Dande, Danbury Hospital, Dept. of Endocrinol, Danbury, CT 06810, United States (see also Heart Diseases and Conditions).

Keywords for this news article include: Danbury, Cardiology, Connecticut, United States, Cardiomyopathies, Cardiovascular Diseases, Takotsubo Cardiomyopathy, North and Central America, Clinical Trials and Studies, Left Ventricular Dysfunction, Heart Diseases and Conditions

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