New Data from Johns Hopkins University Illuminate Findings in Atherosclerosis
By a News Reporter-Staff News Editor at Obesity & Diabetes Week -- Data detailed on Cardiovascular Diseases and Conditions have been presented. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "Cardiovascular risk factors such as aging, smoking, and insulin resistance may lead to atherosclerosis through various mechanisms of which their association with mitochondrial dysfunction may be one of them. In order to examine this hypothesis, we assessed the association between elevated blood lactate, a marker of mitochondrial dysfunction, and carotid atherosclerosis."
Our news editors obtained a quote from the research from Johns Hopkins University, "From a total of 2066 participants from the Atherosclerosis Risk In Communities Carotid MRI study, 1496 were included for this analysis. Wall Thickness and Lipid core presence were measured using gadolinium-enhanced MRI. Blood lactate was categorized into quartiles (Q1: 9.2 mg/dl). Of the 1496 study participants, 763 (51%) were females, 296 (19.8%) African American, 539 (36%) obese and 308 (20.6%) had diabetes. There was a strong and graded association between lactate and wall thickness [Q1: 1.08 mm (95% CI: 1.01 mm-1.15 mm), Q2: 1.33 mm (95% CI: 1.19 mm-1.47 mm), Q3: 1.44 (95% CI: 1.34 mm-1.54 mm) and Q4: 1.62 (95% CI: 1.53 mm-1.71 mm); p for trend < 0.001] after adjusting for age, gender, ethnicity, stature, body mass index (BMI), waist circumference, LDL, High sensitivity C reactive protein (HsCRP), statin use, thiazolidinedione use, hypertension, and diabetes. This association was attenuated, but still significant, after adjusting for a marker of insulin resistance, the triglyceride/HDL ratio, [Q1: 0.96 mm (95% CI: 0.82 mm-1.10 mm), Q2: 1.17 mm (95% CI: 1.08 mm-1.26 mm), Q3: 1.18 mm (95% CI: 1.07 mm-1.29 mm), Q4: 1.22 mm (95% CI: 1.13 mm-1.31 mm), p for linear trend 0.039]. There was no association of lactate with lipid core presence after adjustment for wall thickness. Blood lactate is associated with carotid atherosclerosis."
According to the news editors, the research concluded: "Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate's association with carotid atherosclerosis may be related to insulin resistance."
For more information on this research see: Association of blood lactate with carotid atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Atherosclerosis, 2013;228(1):249-255. Atherosclerosis can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Atherosclerosis - www.elsevier.com/wps/product/cws_home/522790)
The news editors report that additional information may be obtained by contacting G.P.S. Shantha, Johns Hopkins University, Sch Med, Dept. of Med, Baltimore, MD 21287, United States (see also Cardiovascular Diseases and Conditions).
Keywords for this news article include: Obesity, Maryland, Diabetes, Baltimore, Angiology, Proinsulin, United States, Atherosclerosis, Hyperinsulinism, Arteriosclerosis, Peptide Hormones, Insulin Resistance, North and Central America, Arterial Occlusive Diseases, Glucose Metabolism Disorders, Nutritional and Metabolic Diseases
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