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Findings in the Area of Brain Research Reported from University of Wisconsin


By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on Brain Research is the subject of a report. According to news originating from Madison, Wisconsin, by NewsRx correspondents, research stated, "While moderate calorie restriction (CR) in the absence of malnutrition has been consistently shown to have a systemic, beneficial effect against aging in several animals models, its effect on the brain microstructure in a non-human primate model remains to be studied using post-mortem histopathologic techniques. In the present study, we investigated differences in expression levels of glial fibrillaxy acid protein (GFAP) and beta-amyloid plaque load in the hippocampus and the adjacent cortical areas of 7 Control (ad libitum)-fed and 6 CR male rhesus macaques using immunostaining methods."

Our news journalists obtained a quote from the research from the University of Wisconsin, "CR monkeys expressed significantly lower levels (similar to 30% on average) of GFAP than Controls in the CA region of the hippocampus and entorhinal cortex, suggesting a protective effect of CR in limiting astrogliosis. These results recapitulate the neuroprotective effects of CR seen in shorter-lived animal models. There was a significant positive association between age and average amyloid plaque pathology in these animals, but there was no significant difference in amyloid plaque distribution between the two groups. Two of the seven Control animals (28.6%) and one of the six CR animal (16.7%) did not express any amyloid plaques, five of seven Controls (71.4%) and four of six CR animals (66.7%) expressed minimal to moderate amyloid pathology, and one of six CR animals (16.7%) expressed severe amyloid pathology. That CR affects levels of GFAP expression but not amyloid plaque load provides some insight into the means by which CR is beneficial at the microstructural level, potentially by offsetting the increased load of oxidatively damaged proteins, in this non-human primate model of aging."

According to the news editors, the research concluded: "The present study is a preliminary post-mortem histological analysis of the effects of CR on brain health, and further studies using molecular and biochemical techniques are warranted to elucidate underlying mechanisms. ."

For more information on this research see: Calorie restriction attenuates. astrogliosis but not amyloid plaque load in aged rhesus macaques: A preliminary quantitative imaging study. Brain Research, 2013;1508():1-8. Brain Research can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Brain Research -

The news correspondents report that additional information may be obtained from A. Sridharan, University of Wisconsin, Sch Med & Public Hlth, Dept. of Pathol & Lab Med, Madison, WI 53792, United States (see also Brain Research).

Keywords for this news article include: Madison, Amyloid, Proteins, Wisconsin, United States, Brain Research, North and Central America

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