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Researchers from University of Missouri Detail Findings in Breast Cancer


By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on Breast Cancer have been published. According to news reporting originating from Kansas City, Missouri, by NewsRx correspondents, research stated, "Estrogen metabolism-mediated oxidative stress is suggested to play an important role in estrogen-induced breast carcinogenesis. We have earlier demonstrated that antioxidants, vitamin C (Vit C) and butylated hydroxyanisole (BHA) inhibit 17 beta-estradiol (E2)-mediated oxidative stress and oxidative DNA damage, and breast carcinogenesis in female August Copenhagen Irish (ACI) rats."

Our news editors obtained a quote from the research from the University of Missouri, "The objective of the present study was to characterize the mechanism by which above antioxidants prevent DNA damage during breast carcinogenesis. Female ACI rats were treated with E2; Vit C; Vit C + E2; BHA; and BHA + E2 for up to 240 days. mRNA and protein levels of a DNA repair enzyme 8-Oxoguanine DNA glycosylase (OGG1) and a transcription factor NRF2 were quantified in the mammary and mammary tumor tissues of rats after treatment with E2 and compared with that of rats treated with antioxidants either alone or in combination with E2. The expression of OGG1 was suppressed in mammary tissues and in mammary tumors of rats treated with E2. Expression of NRF2 was also significantly suppressed in E2-treated mammary tissues and in mammary tumors. Vitamin C or BHA treatment prevented E2-mediated decrease in OGG1 and NRF2 levels in the mammary tissues. Chromatin immunoprecipitation analysis confirmed that antioxidant-mediated induction of OGG1 was through increased direct binding of NRF2 to the promoter region of OGG1. Studies using silencer RNA confirmed the role of OGG1 in inhibition of oxidative DNA damage."

According to the news editors, the research concluded: "Our studies suggest that antioxidants Vit C and BHA provide protection against oxidative DNA damage and E2-induced mammary carcinogenesis, at least in part, through NRF2-mediated induction of OGG1."

For more information on this research see: Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer. BMC Cancer, 2013;13():1-9. BMC Cancer can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central -; BMC Cancer -

The news editors report that additional information may be obtained by contacting B. Singh, University of Missouri, Sch Pharm, Div Pharmacol & Toxicol, Kansas City, MO 64108, United States (see also Breast Cancer).

Keywords for this news article include: Antioxidants, Missouri, Oncology, Treatment, DNA Damage, Proteomics, Kansas City, DNA Research, United States, Breast Cancer, Women's Health, Protective Agents, Deoxyribonucleic Acid, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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