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Reports from M. Pirro et al Highlight Recent Findings in Cardiovascular Diseases and Disorders


By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on Cardiovascular Diseases and Disorders have been presented. According to news reporting originating in Perugia, Italy, by NewsRx journalists, research stated, "Ectopic artery calcification has been documented in women with postmenopausal osteoporosis, in whom an imbalance in the number of circulating osteoprogenitor cells (OPCs) has been identified. Circulating OPCs form calcified nodules in vitro; however, it remains unknown whether an association exists between the number of circulating OPCs and aortic calcifications."

The news reporters obtained a quote from the research, "We investigated the relationship between OPCs and aortic calcifications in women with postmenopausal osteoporosis. The number of circulating OPCs was quantified by FACS analysis in 50 osteoporotic postmenopausal women. OPCs were defined as CD15-/ alkaline-phosphatase(AP)+ cells coexpressing or not CD34. Participants underwent measurement of markers of bone metabolism, bone mineral density and abdominal aortic calcium (AAC) by 64-slice computed tomography. Patients with AAC were older, had lower 25(OH) vitamin D levels and higher circulating CD15-/ AP+/CD34-cells than those without AAC. Significant correlates of AAC included age (rho Z 0.38 p = 0.006), calcium (rho = 0.35 p = 0.01), 25(OH) vitamin D (rho Z -0.31, p = 0.03) and the number of CD15-/ AP+/ CD34- cells (rho Z 0.55 p< 0.001). In regression analyses, the log-transformed number of CD15-/ AP+/ CD34- cells was associated with the presence (OR Z6.45, 95% CI 1.03-40.1, p=0.04) and severity (beta 0.43, p< 0.001) of AAC, independent of age, 25(OH) vitamin D, calcium and other potential confounders."

According to the news reporters, the research concluded: "Patients with low 25(OH) vitamin D and high CD15-/ AP+/ CD34- cells had higher median AAC than other patients (1927/mu L, 862e2714/mu L vs 147/mu L, 0e1665/mu L, p = 0.003)."

For more information on this research see: Association between circulating osteoblast progenitor cells and aortic calcifications in women with postmenopausal osteoporosis. Nutrition Metabolism and Cardiovascular Diseases, 2013;23(5):466-472. Nutrition Metabolism and Cardiovascular Diseases can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England (see also Cardiovascular Diseases and Disorders).

Our news correspondents report that additional information may be obtained by contacting M. Pirro, Hosp S Maria Misericordia, Radiol Unit, Perugia, Italy.

Keywords for this news article include: Italy, Europe, Perugia, Osteoblasts, Connective Tissue Cells, Metabolic Bone Diseases, Postmenopausal Osteoporosis, Cardiovascular Diseases and Disorders

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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