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Researchers from Rush University Report on Findings in Chronic Hepatitis C Virus


By a News Reporter-Staff News Editor at Hepatitis Weekly -- Investigators publish new report on Virus Diseases. According to news originating from Chicago, Illinois, by NewsRx correspondents, research stated, "The circulating 25-hydroxylated form of vitamin D-3, 25(OH)D, and serum ferritin concentrations have been described to be associated with disease progression in chronic hepatitis C. Both parameters also have been assessed with regard to treatment outcome, however, with divergent results. This study examined both the pre- and posttreatment serum concentrations of 25(OH)D and ferritin in 191 patients infected chronically with hepatitis C virus (HCV) type 1 with regard to liver inflammatory activity (grading), disease progression in terms of fibrosis (staging) and an antiviral treatment outcome."

Our news journalists obtained a quote from the research from Rush University, "Mean pretreatment serum 25(OH)D and ferritin concentrations were 18 +/- 10ng/ml and 280 +/- 225 mu g/L, respectively. Multivariate analysis revealed lower pretreatment serum 25(OH)D and higher ferritin concentrations to be significantly related to both severity of inflammatory activity and of fibrotic alterations. Pretreatment serum ferritin concentration, furthermore, unlike 25(OH)D concentration, was found to be associated with a sustained virological response by uni- and multivariate analyses. A sustained virological response was featured by a significant increase in serum 25(OH)D levels (18 +/- 10ng/ml vs. 22 +/- 11ng/ml; P<0.01), a reduction of serum ferritin concentration (191 +/- 156 mu g/L vs. 103 +/- 63 mu g/L; P<0.001) and a normalization of serum alanine aminotransferase (ALT) and -glutamyl-transferase (-GT) activities."

According to the news editors, the research concluded: "Taken together, decreased 25(OH)D and increased ferritin serum levels indicate the severity of hepatic inflammation and fibrosis in patients infected chronically with HCV type 1. Elevated ferritin, furthermore, was found to be an independent predictor for standard IFN-based therapy responsiveness. J. Med. Virol. 85:1534-1541, 2013."

For more information on this research see: Vitamin D status and serum ferritin concentration in chronic hepatitis C virus type 1 infection. Journal of Medical Virology, 2013;85(9):1534-1541. Journal of Medical Virology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Journal of Medical Virology -

The news correspondents report that additional information may be obtained from A. Amanzada, Rush University, Medical Center, Div Liver Dis, Chicago, IL 60612, United States. Additional authors for this research include A.D. Goralczyk, F. Moriconi, D.H. van Thiel, G. Ramadori and S. Mihm (see also Virus Diseases).

Keywords for this news article include: HCV, Chicago, Viruses, Illinois, Virology, Treatment, Hepatology, United States, Liver Diseases, Virus Diseases, Gastroenterology, Infectious Disease, North and Central America, Chronic Hepatitis C Virus, Digestive System Diseases

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