Reports from Inonu University Add New Data to Findings in Vitamin D Deficiency
By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in Diet and Nutrition Disorders. According to news reporting from Malatya, Turkey, by NewsRx journalists, research stated, "Associations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients."
The news correspondents obtained a quote from the research from Inonu University, "In nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol. While mean 25(OH)D significantly increased from (10.2 +/- A 4.9 ng/ml) to (82.9 +/- A 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 +/- A 3.6) to (2.8 +/- A 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 +/- A 17.6 ng/ml) significantly increased (18.1 +/- A 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 +/- A 276.6 pg/ml to 434.0 +/- A 273.4 ng/ml. Cholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance."
According to the news reporters, the research concluded: "The results of this study need to be confirmed in larger clinical trials."
For more information on this research see: Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients. International Urology and Nephrology, 2013;45(3):879-884. International Urology and Nephrology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; International Urology and Nephrology - www.springerlink.com/content/0301-1623/)
Our news journalists report that additional information may be obtained by contacting O. Ulutas, Inonu University, Fac Med, Dept. of Biochem, Malatya, Turkey. Additional authors for this research include H. Taskapan, M.C. Taskapan and I. Temel (see also Diet and Nutrition Disorders).
Keywords for this news article include: Turkey, Leptin, Malatya, Eurasia, Therapy, Diabetes, Adipokines, Proinsulin, Adiponectin, Avitaminosis, Malnutrition, Renal Dialysis, Hyperinsulinism, Peptide Hormones, Insulin Resistance, Deficiency Diseases, Peritoneal Dialysis, Vitamin D Deficiency, Clinical Trials and Studies, Diet and Nutrition Disorders
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