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New Brain Disease Findings from Institute for Clinical Neurobiology Reported


By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Research findings on Central Nervous System Diseases are discussed in a new report. According to news originating from Vienna, Austria, by NewsRx correspondents, research stated, "Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology."

Our news journalists obtained a quote from the research from Institute for Clinical Neurobiology, "HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5-30 % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging."

According to the news editors, the research concluded: "Unfortunately, there is no therapy or preventive strategy currently available."

For more information on this research see: Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease. Acta Neuropathologica, 2013;126(2):161-177. Acta Neuropathologica can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Acta Neuropathologica -

The news correspondents report that additional information may be obtained from P.T. Nelson, Inst Clin Neurobiol, A-1070 Vienna, Austria. Additional authors for this research include C.D. Smith, E.L. Abner, B.J. Wilfred, W.X. Wang, J.H. Neltner, M. Baker, D.W. Fardo, R.J. Kryscio, S.W. Scheff, G.A. Jicha, K.A. Jellinger, L.J. Van Eldik and F.A. Schmitt (see also Central Nervous System Diseases).

Keywords for this news article include: Vienna, Europe, Austria, Brain Diseases, Central Nervous System Diseases

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