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Study Results from University of Colorado Update Understanding of Putrescine


By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Putrescine is the subject of a report. According to news reporting originating from Boulder, Colorado, by NewsRx correspondents, research stated, "Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, would improve arterial aging."

Our news editors obtained a quote from the research from the University of Colorado, "Aortic pulse wave velocity (aPWV), a measure of arterial stiffness, was similar to 20% greater in old (0, 28 months) compared with young C57BL6 mice (Y, 4 months, P< 0.05). Arterial endothelium-dependent dilation (EDD), a measure of endothelial function, was similar to 25% lower in 0 (P < 0.05 vs. Y) due to reduced nitric oxide (NO) bioavailability. These impairments were associated with greater arterial oxidative stress (nitrotyrosine), superoxide production, and protein cross-linking (advanced glycation end-products, AGEs) in O (all P< 0.05). Spermidine supplementation normalized aPWV, restored NO-mediated EDD and reduced nitrotyrosine, superoxide, AGEs and collagen in O. These effects of spermidine were associated with enhanced arterial expression of autophagy markers, and in vitro experiments demonstrated that vascular protection by spermidine was autophagy-dependent. Our results indicate that spermidine exerts a potent anti-aging influence on arteries by increasing NO bioavailability, reducing oxidative stress, modifying structural factors and enhancing autophagy."

According to the news editors, the research concluded: "Spermidine may be a promising nutraceutical treatment for arterial aging and prevention of age-associated CVD."

For more information on this research see: The autophagy enhancer spermidine reverses arterial aging. Mechanisms of Ageing and Development, 2013;134(7-8):314-320. Mechanisms of Ageing and Development can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier -; Mechanisms of Ageing and Development -

The news editors report that additional information may be obtained by contacting T.J. LaRocca, University of Colorado, Dept. of Integrat Physiol, Boulder, CO 80309, United States. Additional authors for this research include R.A. Gioscia-Ryan, C.M. Hearon and D.R. Seals (see also Putrescine).

Keywords for this news article include: Boulder, Colorado, Polyamines, Putrescine, Spermidine, Nitric Oxide, United States, Biogenic Amines, Organic Chemicals, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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