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Findings from First Hospital in Gastric Cancer Reported


By a News Reporter-Staff News Editor at Preventive Medicine Week -- Data detailed on Oncology have been presented. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "The association between dietary fiber intake and gastric cancer risk has been investigated by many studies, with inconclusive results. We conducted a meta-analysis of case-control and cohort studies to analyze this association."

Our news journalists obtained a quote from the research from First Hospital, "Relevant studies were identified by searching PubMed and Embase through October 2012. We analyzed 21 articles, which included 580,064 subjects. Random-effects models were used to estimate summary relative risks. Dose-response, subgroup, sensitivity, meta-regression, and publication bias analyses were performed. The summary odds ratios of gastric cancer for the highest, compared with the lowest, dietary fiber intake was 0.58 (95% confidence interval, 0.49-0.67) with significant heterogeneity among studies (P < .001, I-2 = 62.2%). Stratified analysis for study design, geographic area, source and type of fiber, Lauren's classification, publication year, sample size, and quality score of study yielded consistent results. Dose-response analysis associated a 10-g/day increment in fiber intake with a significant (44%) reduction in gastric cancer risk. Sensitivity analysis restricted to studies with control for conventional risk factors produced similar results, and omission of any single study had little effect on the combined risk estimate. In a meta-analysis, we show that dietary fiber intake is associated inversely with gastric cancer risk; the effect probably is independent of conventional risk factors. The direction of the protective association of dietary fiber was consistent among all studies, but the absolute magnitude was less certain because of heterogeneity among the studies."

According to the news editors, the research concluded: "Further studies therefore are required to establish this association."

For more information on this research see: Dietary Fiber Intake Reduces Risk for Gastric Cancer: A Meta-analysis. Gastroenterology, 2013;145(1):113-120,491-493. Gastroenterology can be contacted at: W B Saunders Co-Elsevier Inc, 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, PA 19103-2899, USA. (Elsevier -; Gastroenterology -

Our news journalists report that additional information may be obtained by contacting Z.Z. Zhang, Nanjing First Hosp, Dept. of Neurol, Nanjing, Jiangsu, People's Republic of China. Additional authors for this research include G.L. Xu, M.M. Ma, J. Yang and X.F. Liu (see also Oncology).

Keywords for this news article include: Asia, Jiangsu, Oncology, Gastric Cancer, Gastroenterology, Risk and Prevention, People's Republic of China

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