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Study Results from Tohoku University in the Area of Hepatocellular Carcinoma Reported


By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Digestive System Diseases and Conditions have been published. According to news originating from Sendai, Japan, by NewsRx correspondents, research stated, "Vitamin E is the generic name for tocopherol (Toc) and tocotrienol (T3), which have saturated and unsaturated side chains, respectively. Such differences allow T3 to be different from Toc in terms of their functions."

Our news journalists obtained a quote from the research from Tohoku University, "T3 has been known to attenuate cholesterol (Cho) level by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR). Recent reports also showed the efficacy of T3 in improving triglyceride (TG) profiles in both in vivo and in vitro studies. However the mechanism involved in this biological activity is still unclear and needs to be further investigated. In the present study, we elucidated the effect of ?-T3 on lipid levels and lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. ?-T3 showed attenuation of TG through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1, stearoyl CoA desaturase 1, and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6. In contrast, the Cho level remained unchanged. These results expanded our previous finding of lipid-lowering effects of T3, especially for TG."

According to the news editors, the research concluded: "Therefore, T3 is a potential lipid-lowering compound candidate with realistic prospects for its use as a therapy for lipid-related diseases in humans."

For more information on this research see: ?-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. Journal of Nutritional Science and Vitaminology, 2013;59(2):148-51 (see also Digestive System Diseases and Conditions).

The news correspondents report that additional information may be obtained from G.C. Burdeos, Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. Additional authors for this research include K. Nakagawa, A. Watanabe, F. Kimura and T. Miyazawa.

Keywords for this news article include: Asia, Japan, Sendai, Oncology, Hepatocellular Carcinoma, Digestive System Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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