Reports from University of Lodz Add New Data to Findings in Helicobacter pylori
By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on Gram-Negative Bacteria are presented in a new report. According to news reporting originating in Lodz, Poland, by NewsRx journalists, research stated, "Helicobacter pylori (H. pylori) infection plays an important role in gastric carcinogenesis. This bacterium may induce cancer transformation and change the susceptibility of gastric mucosa cells to various exogenous dietary irritants."
The news reporters obtained a quote from the research from the University of Lodz, "The aim of the study was to evaluate the influence of H. pylori infection on the reaction of the stomach cells to a genotoxic effect of heterocyclic amines (HCAs). These well-known mutagens are formed during cooking of protein-rich foods, primarily meat. Taking into account that persons consuming a mixed-western diet are exposed to these compound nearly an entire lifetime and more than half of human population is infected with H. pylori, it is important to assess the combined effect of H. pylori infection and HCAs in the context of DNA damage in gastric mucosa cells, which is a prerequisite to cancer transformation. We employed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) because these substances are present in a great amount in cooked and fried meat. Using alkaline comet assay, we showed that the extent of the DNA damage induced by HCAs was significantly higher in H. pylori infected gastric mucosa cells than in non-infected counterparts. We did not observed any difference in the efficiency of repair of DNA lesions induced by HCAs in both type of cells. Vitamin C reduced the genotoxic effects of HCAs in H. pylori infected and non-infected gastric mucosa cells. Melatonin more effectively decreased DNA damage caused by HCAs in H. pylori infected gastric mucosa cells as compared with control."
According to the news reporters, the research concluded: "Our results suggest that H. pylori infection may influence the susceptibility of gastric mucosa cells to HCAs and dietary antioxidative substances, including vitamin C and melatonin may inhibit the genotoxic effects of HCAs on gastric mucosa cells and may reduce the risk of carcinogenesis caused by food borne mutagens and H. pylori infection."
For more information on this research see: Helicobacter pylori infection and antioxidants can modulate the genotoxic effects of heterocyclic amines in gastric mucosa cells. Molecular Biology Reports, 2013;40(8):5205-5212. Molecular Biology Reports can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Molecular Biology Reports - www.springerlink.com/content/0301-4851/)
Our news correspondents report that additional information may be obtained by contacting T. Poplawski, Medical Univ Lodz, Dept. of Gastroenterol & Internal Dis, Lodz, Poland. Additional authors for this research include C. Chojnacki, A. Czubatka, G. Klupinska, J. Chojnacki and J. Blasiak (see also Gram-Negative Bacteria).
Keywords for this news article include: Lodz, Antioxidants, Poland, Europe, Amines, DNA Damage, Proteomics, DNA Research, Gastroenterology, Organic Chemicals, Protective Agents, Helicobacter pylori, Deoxyribonucleic Acid, Epsilonproteobacteria, Gram-Negative Bacteria
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