Reports Outline Insulin Resistance Findings from Isfahan University of Medical Sciences
By a News Reporter-Staff News Editor at Diabetes Week -- Data detailed on Nutritional and Metabolic Diseases and Conditions have been presented. According to news reporting from Esfahan, Iran, by NewsRx journalists, research stated, "Unfavorable metabolic profiles and oxidative stress in pregnancy are associated with several complications. This study was conducted to determine the effects of vitamin D supplementation on serum concentrations of high-sensitivity C-reactive protein (hs-CRP), metabolic profiles, and biomarkers of oxidative stress in healthy pregnant women."
The news correspondents obtained a quote from the research from the Isfahan University of Medical Sciences, "This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 pregnant women aged 18-40 y old at 25 wk of gestation. Participants were randomly assigned to receive either 400 IU/d cholecalciferol supplements (n = 24) or placebo (n = 24) for 9 wk. Fasting blood samples were taken at study baseline and after 9 wk of intervention to quantify serum concentrations of hs-CRP, lipid concentrations, insulin, and biomarkers of oxidative stress. After 9 wk of intervention, the increases in serum 25-hydroxyvitamin D and calcium concentrations were greater in the vitamin D group (+3.7 mu g/L and +0.20 mg/dL, respectively) than in the placebo group (-1.2 mu g/L and -0.12 mg/dL, respectively; P< 0.001 for both). Vitamin D supplementation resulted in a significant decrease in serum hs-CRP (vitamin D vs. placebo groups: -1.41 vs. +1.50 mu g/mL; P-interaction = 0.01) and insulin concentrations (vitamin D vs. placebo groups: -1.0 vs. +2.6 mu lU/mL; P-interaction = 0.04) and a significant increase in the Quantitative Insulin Sensitivity Check Index score (vitamin D vs. placebo groups: +0.02 vs. -0.02; P-interaction = 0.006), plasma total antioxidant capacity (vitamin D vs. placebo groups: +152 vs. -20 mmol/L; P-interaction = 0.002), and total glutathione concentrations (vitamin D vs. placebo groups: +205 vs. -32 mu mol/L; P-interaction = 0.02) compared with placebo. Intake of vitamin D supplements led to a significant decrease in fasting plasma glucose (vitamin D vs. placebo groups: -0.65 vs. -0.12 mmol/L; P-interaction = 0.01), systolic blood pressure (vitamin D vs. placebo groups: -0.2 vs. +5.5 mm Hg; P-interaction = 0.01), and diastolic blood pressure (vitamin D vs. placebo groups: -0.4 vs. +3.1 mm Hg; P-interaction = 0.01) compared with placebo."
According to the news reporters, the research concluded: "Vitamin D supplementation for 9 wk among pregnant women has beneficial effects on metabolic status."
For more information on this research see: Vitamin D Supplementation Affects Serum High-Sensitivity C-Reactive Protein, Insulin Resistance, and Biomarkers of Oxidative Stress in Pregnant Women. Journal of Nutrition, 2013;143(9):1432-1438. Journal of Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nutrition - www.hindawi.com/journals/jnume/)
Our news journalists report that additional information may be obtained by contacting Z. Asemi, Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dep Community Nutr, Esfahan, Iran. Additional authors for this research include M. Samimi, Z. Tabassi, H. Shakeri and A. Esmailzadeh (see also Nutritional and Metabolic Diseases and Conditions).
Keywords for this news article include: Iran, Asia, Esfahan, Albumins, Diabetes, Immunology, Proinsulin, Proteomics, Immunoproteins, Hyperinsulinism, Peptide Hormones, C Reactive Protein, C-Reactive Protein, Insulin Resistance, Acute-Phase Proteins, Clinical Trials and Studies, Glucose Metabolism Disorders, Nutritional and Metabolic Diseases and Conditions
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