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Researchers from Medical University Describe Findings in Cholesterol


By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on Cholesterol have been published. According to news reporting out of Warsaw, Poland, by NewsRx editors, research stated, "Folic acid (FA) is one of the B complex vitamins. It is thought that FA deficiency promotes atherosclerosis formation in arterial endothelium."

Our news journalists obtained a quote from the research from Medical University, "FA, acting through reducing homocysteine (Hcy) levels, may contribute to decreased cholesterol (Ch) synthesis. The aim of this study was to analyze the association of low-dose folic acid supplementation with blood lipids concentrations in subjects with atherosclerosis risk factors. The study enrolled 124 Caucasian individuals (60 M, ages 20-39; and 64 F, ages 19-39) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hypertension, dyslipidemia, overweight and obesity, cigarette smoking, and low level of physical activity). The participants were asked to take FA at a low dose of 0.4 mg/24 h for 12 weeks. FA levels increased in females (6.3 vs. 12.5 ng/dL; p=0.001) and males (6.4 vs. 11.4 ng/dL; p=0.001) and Hcy levels decreased (10.6 vs. 8.3 mu mol/L; p=0.001 and 11.5 vs. 9.3; p=0.001, respectively). A significant reduction in mean concentration of total cholesterol in females (203.4 vs. 193.1 mg/dL; p=0.001) and in males (209.5 vs. 201.9; p=0.002) was observed. The low-density lipoprotein cholesterol (LDL-C) levels decreased in females and in males (107.4 vs. 99.9 mg/dL; p=0.001 and 121.5 vs. 115.1; p=0.002, respectively). The apoAI concentrations increased in smoking women and in men with BMI >= 25 kg/m(2) (p=0.032 and p=0.024, respectively)."

According to the news editors, the research concluded: "Low-dose FA supplementation has a beneficial effect on blood lipids through decreasing concentrations of total cholesterol and LDL-C and increasing concentrations of apoAI."

For more information on this research see: Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors. Medical Science Monitor, 2013;19():733-739. Medical Science Monitor can be contacted at: Int Scientific Literature, Inc, 361 Forest Lane, Smithtown, NY 11787, USA (see also Cholesterol).

Our news journalists report that additional information may be obtained by contacting A. Mierzecki, Medical University of Warsaw, Dept. of Pharmacognosy & Mol Basis Phytotherapy, Warsaw, Poland. Additional authors for this research include K. Kloda, H. Bukowska, K. Chelstowski, M. Makarewicz-Wujec and M. Kozlowska-Wojciechowska.

Keywords for this news article include: Warsaw, Poland, Europe, Cholesterol, Atherosclerosis, Arteriosclerosis, Risk and Prevention, Cardiovascular Diseases, Arterial Occlusive Diseases

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