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Studies from University of L'Aquila Have Provided New Information about Epithelial Cells


By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Epithelial Cells is the subject of a report. According to news originating from L'Aquila, Italy, by NewsRx correspondents, research stated, "Endothelium homeostasis alterations govern the pathogenesis of cardiovascular diseases. Several studies show that vitamins anti-oxidant proprieties rescue the endothelial functions adversely affected by oxidative stress in several diseases."

Our news journalists obtained a quote from the research from the University of L'Aquila, "We investigated the vitamin D anti-oxidant potential in human endothelial cells exposed to H2O2 oxidative stress. Vitamin D protected endothelial cells against H2O2 oxidative stress counteracting the superoxide anion generation, the apoptosis and blocking the extrinsic caspase cascade by positively controlling phospho-active ERKs level. MEKs/ERKs inhibitor U0126 reverted the vitamin D anti-oxidant effects. Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2. ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1. SirT-1 inhibition by Sirtinol reverted the vitamin D anti-oxidant effects."

According to the news editors, the research concluded: "Thus, vitamin D significantly reduced the endothelial malfunction and damage caused by oxidative stress, through the activation of MEKs/ERKs/SirT-1 axis."

For more information on this research see: Vitamin D protects human endothelial cells from H?O? oxidant injury through the Mek/Erk-Sirt1 axis activation. Journal of Cardiovascular Translational Research, 2013;6(2):221-31. Journal of Cardiovascular Translational Research can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer -; Journal of Cardiovascular Translational Research -

The news correspondents report that additional information may be obtained from L. Polidoro, Dept. of Internal Medicine and Public Health, University of L'Aquila, L'Aquila, Italy. Additional authors for this research include G. Properzi, F. Marampon, G.L. Gravina, C. Festuccia, E. Di Cesare, L. Scarsella, C. Ciccarelli, B.M. Zani and C. Ferri (see also Epithelial Cells).

The publisher's contact information for the Journal of Cardiovascular Translational Research is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Italy, Europe, L'Aquila, Epithelial Cells, Endothelial Cells.

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