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Findings in Brain Ischemia Reported from Division of Nutrition


By a News Reporter-Staff News Editor at Blood Weekly -- Research findings on Cardiovascular Diseases and Conditions are discussed in a new report. According to news originating from Yokaichi, Japan, by NewsRx correspondents, research stated, "While the neuroprotective effect of green tea (Camellia sinensis) might be explained by the presence of amino acid L-theanine in the tea leaves, it is not known whether postischemic administration of L-theanine could also provide neuroprotection. In the present study, we investigated the neuroprotective effect of L-theanine (1 and 4mg/kg) administered at 3, 12, and 24h after reperfusion in the rat model of stroke."

Our news journalists obtained a quote from the research from the Division of Nutrition, "We also studied the effect of L-theanine on brain injury caused by exogenous administration of N-methyl-D-aspartate and -amino-3-hydroxy-5-methyl-isoxazole-4-propionate/kainate receptor agonists during reperfusion. Rats were subjected to 30-min middle cerebral artery occlusion followed by 48-h reperfusion. Neurological deficit and infarct size were determined at the end of reperfusion. At 3 and 12h, but not at 24h of reperfusion, L-theanine substantially reduced the size of brain infarct. Neurological status was improved when L-theanine was administered 3, 12, and 24h after reperfusion. Repeated intrastriatal injections of L-theanine at a total dose of 800 mu g/kg during reperfusion prevented brain injury caused by glutamate receptor agonists."

According to the news editors, the research concluded: "L-theanine at reperfusion exerts neuroprotective effect in the in vivo rat model of stroke. Local treatment with L-theanine at reperfusion prevents glutamate receptor agonist-mediated brain injury."

For more information on this research see: L-theanine Administration Results in Neuroprotection and Prevents Glutamate Receptor Agonist-Mediated Injury in the Rat Model of Cerebral Ischemia-Reperfusion. Phytotherapy Research, 2013;27(9):1282-1287. Phytotherapy Research can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Phytotherapy Research -

The news correspondents report that additional information may be obtained from M. Zukhurova, Taiyo Kagaku Co Ltd, Div Nutr, Yokaichi, Japan. Additional authors for this research include M. Prosvirnina, A. Daineko, A. Simanenkova, N. Petrishchev, D. Sonin, M. Galagudza, M. Shamtsyan, L.R. Juneja and T. Vlasov (see also Cardiovascular Diseases and Conditions).

Keywords for this news article include: Asia, Japan, Yokaichi, Reperfusion, Glutamic Acid, Brain Injuries, Brain Ischemia, Medical Devices, Blood Transfusion, Membrane Proteins, Glutamate Receptors, Amino Acid Receptors, Transfusion Medicine, Craniocerebral Trauma, Cardiovascular Diseases and Conditions

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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