Investigators at University of Copenhagen Zero in on Chronic Kidney Disease
By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on Chronic Kidney Disease are presented in a new report. According to news reporting originating from Copenhagen, Denmark, by NewsRx correspondents, research stated, "Focus on non-classical effects and possible less side effects of treatment with nutritional vitamin D, raises the expectation of possible benefits from treating chronic kidney disease (CKD) patients with ergocalciferol (vitamin D2). Treatment with 1,25(OH)2 vitamin D (calcitriol) induces elevated fibroblast growth factor 23 (FGF23), while epidemiological studies have found positive effects of nutritional and 25(OH)vitamin D on mortality in CKD."
Our news editors obtained a quote from the research from the University of Copenhagen, "Disturbed mineral homeostasis in CKD is correlated to adverse outcome and cardiovascular mortality. The objective was to examine the possible effects of treatment with high doses of ergocalciferol on parameters of mineral homeostasis in predialysis CKD patients. A total of 43 adult patients with CKD stage 4-5, not receiving vitamin D supplementation, were studied, and allocated by simple randomization to either an intervention (n&) or a control group (n). The intervention group received ergocalciferol, 50.000 IU/week for 6 weeks. Plasma FGF23, creatinine, parathyroid hormone (PTH), phosphate and ionized calcium were obtained at baseline and after the 6 weeks. The intervention group had a significant increase in 25(OH)D2 concentration from <10 to 90 ?? 4 nmol/L, while 1,25(OH)2D (62 ?? 6 at baseline and 67 ?? 6 pmol/L at 6 weeks) remained stable. No changes were seen in the circulating vitamin D concentrations in the control group. After the 6 weeks of treatment no significant changes were seen in concentration of creatinine, phosphate, ionized calcium, PTH and FGF23 remained stable."
According to the news editors, the research concluded: "No harmful effects of short-term treatment with high-dose ergocalciferol were observed on markers of mineral homeostasis and FGF23 in CKD patients stage 4-5."
For more information on this research see: Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4-5. Scandinavian Journal of Clinical and Laboratory Investigation, 2013;73(2):107-16 (see also Chronic Kidney Disease).
The news editors report that additional information may be obtained by contacting E. Gravesen, University of Copenhagen, Nephrological Dept. of P, Rigshospitalet, Copenhagen, Denmark. Additional authors for this research include J. Hofman-Bang, E. Lewin and K. Olgaard.
Keywords for this news article include: Europe, Denmark, Treatment, Copenhagen, Chronic Kidney Disease.
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