Study Results from Uniformed Services University of the Health Sciences in the Area of Prostate Cancer Reported
By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Oncology. According to news reporting originating from Bethesda, Maryland, by NewsRx correspondents, research stated, "Mechanisms underlying progression to androgen-independent prostate cancer following radical ablation therapy remain poorly defined. Although intraprostatic infections have been highlighted as potential cofactors, pathogen influences on pathways that support tumor regrowth are not known."
Our news editors obtained a quote from the research from the Uniformed Services University of the Health Sciences, "To explore this provocative concept, we derived androgen-sensitive and -insensitive prostate epithelial cells persistently infected with human herpesvirus 8 (HHV-8), an oncogenic herpesvirus that has been detected in normal prostate epithelium, prostate adenocarcinoma, and biologic fluids of patients with prostate cancer, to explore its effects on transition to hormone-refractory disease. Strikingly, we found that HHV-8 infection of androgen-sensitive prostate cancer cells conferred the capacity for androgen-independent growth. This effect was associated with altered expression and transcriptional activity of the androgen receptor (AR). However, HHV-8 infection bypassed AR signaling by promoting enhancer of zeste homolog 2 (EZH2)-mediated epigenetic silencing of tumor-suppressor genes, including MSMB and DAB2IP that are often inactivated in advanced disease. Furthermore, we found that HHV-8 triggered epithelial-to-mesenchymal transition. Although HHV-8 has not been linked etiologically to prostate cancer, virologic outcomes revealed by our study provide mechanistic insight into how intraprostatic infections could constitute risk for progression to androgen-independent metastatic disease where EZH2 has been implicated."
According to the news editors, the research concluded: "Taken together, our findings prompt further evaluations of the relationship between HHV-8 infections and risk of advanced prostate cancer."
For more information on this research see: Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth. Cancer Research, 2013;73(18):5695-5708. Cancer Research can be contacted at: Amer Assoc Cancer Research, 615 Chestnut St, 17TH Floor, Philadelphia, PA 19106-4404, USA. (American Association for Cancer Research - www.aacr.com; Cancer Research - cancerres.aacrjournals.org/)
The news editors report that additional information may be obtained by contacting J.G. Mygatt, Uniformed Services University for Health Science, Dept. of Microbiol & Immunol, Emerging Infect Dis Program, Bethesda, MD 20814, United States. Additional authors for this research include A. Singhal, G. Sukumar, C.L. Dalgard and J.A.R. Kaleeba (see also Oncology).
Keywords for this news article include: Therapy, Bethesda, Maryland, Genetics, Hormones, Oncology, Virology, Herpes Virus, United States, Prostate Cancer, Prostatic Neoplasms, North and Central America, Androgens and Anabolic Steroids
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