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Studies from Johns Hopkins University School of Medicine Have Provided New Data on HIV/AIDS


By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on Immune System Diseases and Conditions have been published. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "Patients with HIV infection are at increased risk for coronary artery disease (CAD), and growing evidence suggests a possible link between vitamin D deficiency and clinical/subclinical CAD. However, the relationship between vitamin D deficiency and coronary artery calcification (CAC), a sensitive marker for subclinical CAD, in those with HIV infection is not well investigated."

Our news editors obtained a quote from the research from the Johns Hopkins University School of Medicine, "CAC was quantified using a Siemens Cardiac 64 scanner, and vitamin D levels and the presence of traditional and novel risk factors for CAD were obtained in 846 HIV-infected African American (AA) participants aged 25 years or older in Baltimore, MD, USA without symptoms or clinical evidence of CAD. The prevalence of vitamin D deficiency (25-hydroxy vitamin D<10 ng/mL) was 18.7%. CAC was present in 238 (28.1%) of the 846 participants. Logistic regression analysis revealed that the following factors were independently associated with CAC: age (adjusted odds ratio [OR]: 1.11; 95% confidence interval [CI]: 1.08-1.14); male sex (adjusted OR: 1.71; 95% CI: 1.18-2.49); family history of CAD (adjusted OR: 1.53; 95% CI: 1.05-2.23); total cholesterol (adjusted OR: 1.006; 95% CI: 1.002-1.010); high-density lipoprotein cholesterol (adjusted OR: 0.989; 95% CI: 0.979-0.999); years of cocaine use (adjusted OR: 1.02; 95% CI: 1.001-1.04); duration of exposure to protease inhibitors (adjusted OR: 1.004; 95% CI: 1.001-1.007); and vitamin D deficiency (adjusted OR: 1.98; 95% CI: 1.31-3.00). Both vitamin D deficiency and CAC are prevalent in AAs with HIV infection. In order to reduce the risk for CAD in HIV-infected AAs, vitamin D levels should be closely monitored."

According to the news editors, the research concluded: "These data also suggest that clinical trials should be conducted to examine whether vitamin D supplementations reduce the risk of CAD in this AA population."

For more information on this research see: Vitamin D deficiency is associated with coronary artery calcification in cardiovascularly asymptomatic African Americans with HIV infection. Vascular Health and Risk Management, 2013;9():493-500 (see also Immune System Diseases and Conditions).

The news editors report that additional information may be obtained by contacting S. Lai, Dept. of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, United States. Additional authors for this research include E.K. Fishman, G. Gerstenblith, J. Brinker, H. Tai, S. Chen, J. Li, W. Tong, B. Detrick and H. Lai.

Keywords for this news article include: Maryland, HIV/AIDS, Baltimore, Angiology, Cardiology, RNA Viruses, Retroviridae, United States, Cardiovascular, HIV Infections, Coronary Artery, Vertebrate Viruses, Primate Lentiviruses, North and Central America, Clinical Trials and Studies, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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