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Data from Hyogo College of Medicine Provide New Insights into Epithelial Cells


By a News Reporter-Staff News Editor at Drug Week -- New research on Epithelial Cells is the subject of a report. According to news originating from Nishinomiya, Japan, by NewsRx correspondents, research stated, "Dysfunction of he innate immune system has been reported to cause intestinal inflammation. Vitamin D3 is known to be an important immune system regulator and exerts anti-inflammatory effects."

Our news journalists obtained a quote from the research from the Hyogo College of Medicine, "We investigated in vitro effects of vitamin D3 and its derivatives on the innate immune system in HT-29 cells, a line of human colon adenocarcinoma cells. Among the innate immune-related receptors such as Toll-like receptor (TLR) 1, 2, 4, 6, and CD14 examined by flow cytometry, only CD14 was up-regulated by vitamin D-3 derivatives. Release of soluble form CD14 (5CD14) was also increased by vitamin D-3 derivatives. The 1a,25-dihydroxy-22-oxavitamin D3 (Oxa-D-3) induced-5CD14 release was inhibited by 1J0126 (a specific inhibitor of extracellular signal-regulated kinase; ERK1 /2) but not by SB203580 (a specific inhibitor of p38 MAPK), and ERK1 /2 phosphorylation was accelerated by Oxa-D-3. These results indicate that Oxa-D3 facilitates the release of sCD14 through ERK1/2 activation. fL-8 production stimulated with [PS was diminishecl by vitamin D3 derivatives. Recombinant 5CD14 also lowered the [PS-stimulated IL-8 production, suggesting neutralization of [PS by 5CD14."

According to the news editors, the research concluded: "The anti-inflammatory effect of vitamin D3 derivatives was thus associated with diminution of fL-8 production due to increased release of sCD14."

For more information on this research see: Vitamin D-3 derivatives increase soluble CD14 release through ERK1/2 activation and decrease IL-8 production in intestinal epithelial cells. European Journal of Pharmacology, 2013;721(1-3):305-312. European Journal of Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; European Journal of Pharmacology -

The news correspondents report that additional information may be obtained from M. Hidaka, Hyogo Coll Med, Dept. of Environm & Prevent Med, Nishinomiya, Hyogo 6638501, Japan. Additional authors for this research include I. Wakabayashi, Y. Takeda and K. Fukuzawa (see also Epithelial Cells).

Keywords for this news article include: Asia, Japan, Nishinomiya, Epithelial Cells

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