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Researchers at National Cancer Center Research Institute Detail Findings in Weight Loss


By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Weight Loss is now available. According to news reporting originating from Tokyo, Japan, by NewsRx correspondents, research stated, "Cachexia, a negative prognostic factor, worsens a patient's quality of life. We established 2 novel cachexia models with the human stomach cancer cell line MKN-45, which was subcloned to produce potent cachexia-inducing cells by repeating the xenografts in immune-deficient mice."

Our news editors obtained a quote from the research from National Cancer Center Research Institute, "After subsequent xenografts, we isolated potent cachexia-inducing cells (MKN45cl85 and 85As2mLuc). Xenografts of MKN45cl85 cells in mice led to substantial weight loss and reduced adipose tissue and musculature volumes, whereas xenografts of 85As2mLuc cells resulted in highly metastatic and cachectic mice. Surgical removal of tumor tissues helped the mice regain body-weight in both mouse models. In vitro studies using these cells showed that isoflavones reduced their proliferation, implying that the isoflavones possess antiproliferative effects of these cancer cell lines. Isoflavone treatment on the models induced tumor cytostasis, attenuation of cachexia, and prolonged survival whereas discontinuation of the treatment resulted in progressive tumor growth and weight loss. The inhibitory effects of tumor growth and weight loss by isoflavones were graded as soy isoflavone aglycone AglyMax >daidzein >genistein."

According to the news editors, the research concluded: "These results demonstrated that the 2 novel cachectic mouse models appear useful for analyzing the mechanism of cancer cachexia and monitoring the efficacy of anticachectic agents."

For more information on this research see: Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers. Nutrition and Cancer, 2013;65(4):578-89 (see also Weight Loss).

The news editors report that additional information may be obtained by contacting K. Yanagihara, Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan. Additional authors for this research include M. Takigahira, K. Mihara, T. Kubo, C. Morimoto, Y. Morita, K. Terawaki, Y. Uezono and T. Seyama.

Keywords for this news article include: Asia, Tokyo, Japan, Cancer, Oncology, Treatment, Weight Loss.

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