Study Results from Science Institute Provide New Insights into Neurodegenerative Diseases
By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators discuss new findings in Nervous System Diseases and Conditions. According to news originating from Sunnyvale, California, by NewsRx correspondents, research stated, "Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans. Of particular importance is how the brain removes potentially toxic biomolecules that accumulate with normal neuronal function."
Our news journalists obtained a quote from the research from Science Institute, "Recently, a biomolecule clearance system using convective flow between the cerebrospinal fluid (CSF) and interstitial fluid (ISF) to remove toxic metabolites in the brain was described. Xie and colleagues now report that in mice the clearance activity of this so-called glymphatic system is strongly stimulated by sleep and is associated with an increase in interstitial volume, possibly by shrinkage of astroglial cells. Moreover, anesthesia and attenuation of adrenergic signaling can activate the glymphatic system to clear potentially toxic proteins known to contribute to the pathology of Alzheimer disease (AD) such as beta-amyloid (Abeta). Clearance during sleep is as much as two-fold faster than during waking hours. These results support a new hypothesis to answer the age-old question of why sleep is necessary. Glymphatic dysfunction may pay a hitherto unsuspected role in the pathogenesis of neurodegenerative diseases as well as maintenance of cognition. Furthermore, clinical studies suggest that quality and duration of sleep may be predictive of the onset of AD, and that quality sleep may significantly reduce the risk of AD for apolipoprotein E (ApoE) 4 carriers, who have significantly greater chances of developing AD. Further characterization of the glymphatic system in humans may lead to new therapies and methods of prevention of neurodegenerative diseases."
According to the news editors, the research concluded: "A public health initiative to ensure adequate sleep among middle-aged and older people may prove useful in preventing AD, especially in apolipoprotein E (ApoE) 4 carriers."
For more information on this research see: Sleep Facilitates Clearance of Metabolites from the Brain: Glymphatic Function in Aging and Neurodegenerative Diseases. Rejuvenation Research, 2013;16(6):518-523. Rejuvenation Research can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Rejuvenation Research - www.liebertpub.com/overview/rejuvenation-research/127/)
The news correspondents report that additional information may be obtained from A.R. Mendelsohn, Regenerat Sci Inst, Sunnyvale, CA 94089, United States (see also Nervous System Diseases and Conditions).
Keywords for this news article include: Sunnyvale, California, United States, North and Central America, Neurodegenerative Diseases, Nervous System Diseases and Conditions
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