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Reports Outline Clinical Endocrinology and Metabolism Findings from University of Zurich


By a News Reporter-Staff News Editor at Clinical Trials Week -- Research findings on Health and Medicine are discussed in a new report. According to news originating from Zurich, Switzerland, by NewsRx correspondents, research stated, "Studies examining whether vitamin D supplementation increases muscle mass or muscle-specific vitamin D receptor (VDR) concentration are lacking. Our objective was to determine whether vitamin D-3 4000 IU/d alters muscle fiber cross-sectional area (FCSA) and intramyonuclear VDR concentration over 4 months."

Our news journalists obtained a quote from the research from the University of Zurich, "This was a randomized, double-blind, placebo-controlled study in a single center. Participants were 21 mobility-limited women (aged >= 65 years) with serum 25-hydroxyvitamin D (25OHD) levels of 22.5 to 60 nmol/L. Baseline and 4-month FCSA and intramyonuclear VDR were measured from vastus lateralis muscle cross-sections probed for muscle fiber type (I/IIa/IIx) and VDR using immunofluorescence. At baseline, mean (+/- SD) age was 78 +/- 5 years; body mass index was 27 +/- 5 kg/m(2), 25OHD was 46.3 +/- 9.5 nmol/L, and a short physical performance battery score was 7.95 +/- 1.57 out of 12. At 4 months, 25OHD level was 52.5 +/- 17.1 (placebo) vs 80.0 +/- 11.5 nmol/L (vitamin D [ VD]; P< .01), and change in 25OHD level was strongly associated with percent change in intramyonuclear VDR concentration-independent of group (r = 0.87, P< .001). By treatment group, percent change in intramyonuclear VDR concentration was 7.8% +/- 18.2% (placebo) vs 29.7% +/- 11.7% (VD; P = .03) with a more pronounced group difference in type II vs I fibers. Percent change in total (type I/II) FCSA was -7.4% +/- 18.9% (placebo) vs 10.6% +/- 20.0% (VD; P = .048). Vitamin D-3 supplementation increased intramyonuclear VDR concentration by 30% and increased muscle fiber size by 10% in older, mobility-limited, vitamin D-insufficient women."

According to the news editors, the research concluded: "Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved."

For more information on this research see: A Randomized Study on the Effect of Vitamin D-3 Supplementation on Skeletal Muscle Morphology and Vitamin D Receptor Concentration in Older Women. Journal of Clinical Endocrinology & Metabolism, 2013;98(12):E1927-E1935. Journal of Clinical Endocrinology & Metabolism can be contacted at: Endocrine Soc, 8401 Connecticut Ave, Suite 900, Chevy Chase, MD 20815-5817, USA. (The Endocrine Society -; Journal of Clinical Endocrinology & Metabolism -

The news correspondents report that additional information may be obtained from L. Ceglia, University of Zurich, City Hosp Waid, Dept. of Geriatr & Aging Res, CH-8091 Zurich, Switzerland. Additional authors for this research include S. Niramitmahapanya, M.D. Morais, D.A. Rivas, S.S. Harris, H. Bischoff-Ferrari, R.A. Fielding and B. Dawson-Hughes (see also Health and Medicine).

Keywords for this news article include: Zurich, Europe, Switzerland, Health and Medicine, Clinical Trials and Studies

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