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Findings from Juntendo University Urayasu Hospital Broaden Understanding of Marchiafava-Bignami Disease


By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on Nervous System Diseases and Conditions are presented in a new report. According to news reporting originating in Urayasu, Japan, by NewsRx journalists, research stated, "Marchiafava-Bignami disease (MBD) is a rare neurologic complication of chronic alcohol consumption that is characterized by callosal lesions involving demyelination and necrosis. Various reversible neurologic symptoms are found in patients with MBD."

The news reporters obtained a quote from the research from Juntendo University Urayasu Hospital, "Dysarthria and dysphagia are found in various neurological diseases. We report a 51-year-old man with chronic alcoholism and malnutrition who progressively developed dysarthria and dysphagia. On admission, the patient was alert with mild cognitive dysfunction. The facial expression was flat, and there was weakness of the orbicularis oris bilaterally. The patient's speech was slurred, there was difficulty swallowing, and the gag reflex and palate elevation were poor. The jaw jerk reflex was brisk and the snout reflex was positive. Neither tongue atrophy nor fasciculation were found. Bilateral upper and lower limb weakness with increased bilateral upper limb reflexes and Babinski reflexes were found. Because he had progressive dysarthria and dysphagia with upper and lower motor neuron signs, the initial diagnosis was motor neuron disease. However, electrophysiological analysis was normal. The vitamin B1 level was 14 ng/mL (normal: >24 ng/mL), and MRI revealed hyperintense lesions in the splenium of the corpus callosum and the primary motor cortices bilaterally. After vitamin B therapy for 17 days, the neurological disorders alleviated concurrently with disappearance of the lesions on MRI, which led to the definitive diagnosis of MBD."

According to the news reporters, the research concluded: "MBD presenting with these lesions can mimic motor neuron disease clinically."

For more information on this research see: Marchiafava-Bignami disease mimics motor neuron disease: case report. Bmc Neurology, 2013;13():208. (BioMed Central -; Bmc Neurology -

Our news correspondents report that additional information may be obtained by contacting Y. Hoshino, Dept. of Neurology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan. Additional authors for this research include Y. Ueno, H. Shimura, N. Miyamoto, M. Watanabe, N. Hattori and T. Urabe (see also Nervous System Diseases and Conditions).

Keywords for this news article include: Asia, Japan, Urayasu, Dysphagia, Dysarthria, Gastroenterology, Speech Disorders, Speech Pathology, Language Disorders, Deglutition Disorders, Articulation Disorders, Demyelinating Diseases, Communication Disorders, Metabolic Brain Diseases, Marchiafava Bignami Disease, Neurobehavioral Manifestations.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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