Findings from Taipei Medical University in the Area of Spinal Cord Injuries Described
By a News Reporter-Staff News Editor at Clinical Trials Week -- Data detailed on Nervous System Diseases and Conditions have been presented. According to news reporting out of Taipei, Taiwan, by NewsRx editors, research stated, "Experimental, controlled, animal study. To assess the effects of vitamins C and E (VCE) treatment on oxidative stress and programmed cell deaths after rat spinal cord injury (SCI), as well as functional recovery. Taiwan."
Our news journalists obtained a quote from the research from Taipei Medical University, "Fifty-four Sprague-Dawley rats were used for the experimental procedure. In the sham group, laminectomy at T10 was performed, followed by impactor contusion of the spinal cord. In the control group, only a laminectomy was performed without contusion. Oxidative stress status was assessed by measuring the spinal cord tissue content of superoxide dismutase (SOD) and gluthatione peroxidase (GSH-Px) activities. We also evaluated the effects of combined VCE treatment using western blot to analyze expression of cleaved caspase-3 and microtubule-associated protein light chain 3 (LC3), and the Basso, Beattie and Bresnahan (BBB) scale to evaluate functional outcomes. Combined treatment of VCE significantly counteracted the effects of spinal cord contusion on oxidative stress represented by activities of SOD and GSH-Px (P <0.05). The VCE treatment also significantly enhanced LC3-II expression and decreased cleaved caspase-3 compared with the sham (P <0.05). Furthermore, BBB scores significantly improved in the VCE-treated group compared with the sham group (on day 14 and 28 after SCI; P<0.05). The combined administration of VCE was clearly capable of modulating the antioxidant effects, and of reducing apoptosis and increasing autophagy at the lesion epicenter leading to an improved functional outcome."
According to the news editors, the research concluded: "Use of such clinically ready drugs could help earlier clinical trials in selected cases of human SCIs."
For more information on this research see: Effects of the combined administration of vitamins C and E on the oxidative stress status and programmed cell death pathways after experimental spinal cord injury. Spinal Cord, 2014;52(1):24-28. Spinal Cord can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Spinal Cord - www.nature.com/sc/)
Our news journalists report that additional information may be obtained by contacting H.C. Chen, Taipei Medical University, Sch Med, Dept. of Anat, Coll Med, Taipei 11031, Taiwan. Additional authors for this research include P.W. Hsu, W.C. Tzaan and A.W. Lee (see also Nervous System Diseases and Conditions).
Keywords for this news article include: Asia, Taipei, Taiwan, Treatment, Spinal Cord Injury, Nervous System Trauma, Central Nervous System, Clinical Trials and Studies, Nervous System Diseases and Conditions
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