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Reports Outline Vitamin D Deficiency Study Results from Erasmus University Medical Center


By a News Reporter-Staff News Editor at Diabetes Week -- Current study results on Diet and Nutrition Disorders have been published. According to news reporting out of Rotterdam, Netherlands, by NewsRx editors, research stated, "Childhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular complications later in life. As vitamin D exhibits profound immunomodulatory functions and vitamin D deficiency is highly prevalent in childhood obesity, we hypothesized that vitamin D deficiency in childhood obesity coincides with enhanced systemic inflammation and reduced insulin sensitivity."

Our news journalists obtained a quote from the research from Erasmus University Medical Center, "In a cross-sectional study of 64 obese and 32 healthy children aged 6-16 years, comprehensive profiling of 32 circulating inflammatory mediators was performed, together with assessment of 25-hydroxyvitamin D (25(OH) D) levels and measures for insulin sensitivity. Severe vitamin D insufficiency, which is further referred to as vitamin D deficiency, was defined as a 25(OH)D level = 50 nmol l(-1)). First, 25(OH)D-deficient obese children showed a lower insulin sensitivity than other obese children, as measured by a lower quantitative insulin sensitivity check index. Second, the association between 25(OH)D deficiency and insulin resistance in childhood obesity was confirmed with multiple regression analysis. Third, 25(OH)D-deficient obese children showed higher levels of the inflammatory mediators cathepsin S, chemerin and soluble vascular adhesion molecule (sVCAM), compared with the other obese children. Finally, hierarchical cluster analysis revealed an over-representation of 25(OH)D deficiency in obese children expressing inflammatory mediator clusters with high levels of cathepsin S, sVCAM and chemerin. 25(OH)D deficiency in childhood obesity was associated with enhanced systemic inflammation and reduced insulin sensitivity."

According to the news editors, the research concluded: "The high cathepsin S and sVCAM levels may reflect activation of a pro-inflammatory, pro-diabetic and atherogenic pathway, which could be inhibited by vitamin D supplementation."

For more information on this research see: Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity. International Journal of Obesity, 2014;38(1):46-52. International Journal of Obesity can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; International Journal of Obesity -

Our news journalists report that additional information may be obtained by contacting M. Reyman, Erasmus MC, Dept. of Virol, Rotterdam, Netherlands. Additional authors for this research include A.A.V. Stuart, M. van Summeren, M. Rakhshandehroo, R. Nuboer, F.K. de Boer, H.J. van den Ham, E. Kalkhoven, B. Prakken and H.S. Schipper (see also Diet and Nutrition Disorders).

Keywords for this news article include: Europe, Obesity, Diabetes, Rotterdam, Bariatrics, Cathepsins, Proinsulin, Netherlands, Avitaminosis, Inflammation, Malnutrition, Overnutrition, Peptide Hormones, Peptide Hydrolases, Deficiency Diseases, Vitamin D Deficiency, Diet and Nutrition Disorders, Nutritional and Metabolic Diseases

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