Report Summarizes Genetics and Acne Vulgaris Study Findings from Department of Dermatology
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Skin Diseases and Conditions. According to news originating from Los Angeles, California, by NewsRx correspondents, research stated, "Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting Propionibacterium acnes has a significant role in its pathogenesis. In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1, but not Th2 responses in human peripheral blood mononuclear cells (PBMCs). P. acnes stimulated expression of key Th17-related genes, including IL-17A, ROR alpha, RORc, IL-17RA, and IL-17RC, and triggered IL-17 secretion from CD4(+), but not from CD8(+) T cells. Supernatants from P. acnes stimulated PBMCs were sufficient to promote the differentiation of naive CD4(+)CD45RA T cells into Th17 cells."
Our news journalists obtained a quote from the research from the Department of Dermatology, "Furthermore, we found that the combination of IL-1 beta, IL-6, and transforming growth factor-beta-neutralizing antibodies completely inhibited P. acnes induced IL-17 production. Importantly, we showed that IL-17-expressing cells were present in skin biopsies from acne patients but not from normal donors. Finally, vitamin A (all-trans retinoic acid) and vitamin D (1,25-dihydroxyvitamin D3) inhibited P. acnes induced Th17 differentiation."
According to the news editors, the research concluded: "Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne."
For more information on this research see: Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D. Journal of Investigative Dermatology, 2014;134(2):366-373. Journal of Investigative Dermatology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Journal of Investigative Dermatology - www.nature.com/jid/)
The news correspondents report that additional information may be obtained from G.W. Agak, Greater Los Angeles Healthcare Syst Vet Affairs, Dept. of Dermatol, Los Angeles, CA, United States. Additional authors for this research include M. Qin, J. Nobe, M.H. Kim, S.R. Krutzik, G.R. Tristan, D. Elashoff, H.J. Garban and J. Kim (see also Skin Diseases and Conditions).
Keywords for this news article include: Genetics, Vitamin A, California, Los Angeles, United States, Acne Vulgaris, Actinobacteria, Actinomycetales, Facial Dermatoses, Gram-Positive Rods, Acneiform Eruptions, Propionibacteriaceae, Gram-Positive Bacteria, Propionibacterium acnes, Sebaceous Gland Diseases, North and Central America, Skin Diseases and Conditions
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