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New Data from National Cheng Kung University Illuminate Findings in Diabetes


By a News Reporter-Staff News Editor at Blood Weekly -- Research findings on Diabetes are discussed in a new report. According to news reporting originating from Tainan, Taiwan, by NewsRx correspondents, research stated, "Rhodiola rosea (Rhodiola) is a plant in the Crassulaceae family that grows in cold regions of the world. It is mainly used in clinics as an adaptogen."

Our news editors obtained a quote from the research from National Cheng Kung University, "Recently, it has been mentioned that Rhodiola increases plasma beta-endorphin to lower blood pressure. Thus, the present study aims to investigate the antidiabetic action of Rhodiola in relation to opioids in streptozotocin-induced diabetic rats (STZ-diabetic rats). In the present study, the plasma glucose was analyzed with glucose oxidase method, and the determination of plasma beta-endorphin was carried out using a commercially available enzyme-linked immunosorbent assay. The adrenalectomy of STZ-diabetic rats was used to evaluate the role of beta-endorphin. In addition, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting analysis were performed to investigate mRNA and protein expressions. Rhodiola-water extract dose-dependently lowered the plasma glucose in STZ-diabetic rats and this action was reversed by blockade of opioid mu-receptors using cyprodime. An increase of plasma beta-endorphin by rhodiola-water extract was also observed in same manner. The plasma glucose lowering action of rhodiola-water extract was attenuated in bilateral adrenalectomized rats. In addition, continuous administration of rhodiola-water extract for 3 days in STZ-diabetic rats resulted in an increased expression of glucose transporter subtype 4 (GLUT 4) in skeletal muscle and a marked reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression in liver. These effects were also reversed by blockade of opioid mu-receptors."

According to the news editors, the research concluded: "Taken together, rhodiola-water extract improves hyperglycemia via an increase of beta-endorphin secretion from adrenal gland to activate opioid mu-receptors in STZ-diabetic rats."

For more information on this research see: Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats. BMC Complementary and Alternative Medicine, 2014;14():10-18. BMC Complementary and Alternative Medicine can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central -; BMC Complementary and Alternative Medicine -

The news editors report that additional information may be obtained by contacting C.S. Niu, National Cheng Kung University, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan. Additional authors for this research include L.J. Chen and H.S. Niu (see also Diabetes).

Keywords for this news article include: Asia, Blood, Tainan, Taiwan, Plasma, Diabetes, Endocrinology, Neuropeptides, beta-Endorphin, Opioid Peptides, Peptide Hormones, Pituitary Hormones, Pro-Opiomelanocortin, Nerve Tissue Proteins

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