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Studies in the Area of Neurochemistry Reported from Vanderbilt University

Pain & Central Nervous System Week


By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Neuroscience. According to news reporting from Nashville, Tennessee, by NewsRx journalists, research stated, "Severe vitamin C deficiency (ascorbic acid; AA) was induced in gulo-/-mice incapable of synthesizing their own AA. A number of behavioral measures were studied before and during the deprivation period, including a scorbutic period, during which weight loss was observed in the mice."

The news correspondents obtained a quote from the research from Vanderbilt University, "Mice were then resuscitated with AA supplements. During the scorbutic period, gulo-/-mice showed decreased voluntary locomotor activity, diminished physical strength, and increased preference for a highly palatable sucrose reward. These behaviors all returned to control levels following resuscitation. Altered trial times in subordinate mice in the tube test for social dominance in the AA-deprived mice persisted following resuscitation and may signify a depressive-like behavior in these mice. Biochemical analyses were undertaken following a second deprivation period. AA deficiency was accompanied by decreased blood glucose levels, oxidative damage to lipids and proteins in the cortex, and decreases in dopamine and serotonin metabolites in both the cortex and striatum."

According to the news reporters, the research concluded: "Given the reasonably high proportions of the population that do not consume sufficient AA in the diet, these data have important implications for physical and psychological function in the general population."

For more information on this research see: Behavioral and monoamine changes following severe vitamin C deficiency. Journal of Neurochemistry, 2013;124(3):363-75. (Wiley-Blackwell -; Journal of Neurochemistry -

Our news journalists report that additional information may be obtained by contacting M.S. Ward, Dept. of Neuroscience, Vanderbilt University, Nashville, TN, United States. Additional authors for this research include J. Lamb, J.M. May and F.E Harrison (see also Neuroscience).

Keywords for this news article include: Nashville, Tennessee, Neuroscience, United States, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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