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Researchers from University of Manitoba Report Findings in Crohn's Disease

Gastroenterology Week


By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators discuss new findings in Inflammatory Bowel Diseases. According to news reporting originating in Winnipeg, Canada, by NewsRx journalists, research stated, "Crohn disease (CD) and ulcerative colitis (UC) are 2 common inflammatory bowel diseases (IBDs) associated with intestinal inflammation and tissue damage. Oxidative stress is suggested to play a major role in the initiation and progression of IBD."

The news reporters obtained a quote from the research from the University of Manitoba, "Vitamin C (ascorbate, ascorbic acid) supplementation has reduced oxidative stress in persons with IBD. The role of ascorbate transporters in IBD remains to be determined. SLC23A1 is a major ascorbate transporter in the intestinal tract, and some of its genetic variants have been associated with severely, decreased ascorbate transport and lower systemic concentrations. This study aimed to determine whether common genetic variants in the vitamin C transporter SLC23A1 are associated with the risk of IBD. Genomic DNA samples from patients with CD (n = 162) and UC (n = 149) from the Manitoba IBD Cohort Study and ethnically matched controls (n = 142) were genotyped for 3 SLC23A1 polymorphisms (rs6596473, rs33972313, and rs10063949) by using TaqMan assays. Variation at rs10063949 (G allele for heterozygote and homozygote) was associated with increased susceptibility to CD (OR: 2.54; 95% CI: 1.38, 4.66; OR: 4.72; 95% Cl: 2.53, 8.81; P< 0.0001; respectively). A strong linkage disequilibrium (LD) was observed across the SLC23A1 region (variation rs6596473 with rs10063949) for CD and UC (D' = 0.94 and 0.96, respectively). The risk alleles confirmed a haplotype (CGG) that is carried more in CD patients (65.3%, P< 0.0001) than in controls (43.5%). A genetic variant (rs10063949-G) in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of CD in a white Canadian IBD cohort."

According to the news reporters, the research concluded: "The presented evidence that SLC23A/ variations can modulate the risk of CD has implications for understanding ascorbate transport in CD patients and provides a novel opportunity toward individualized nutritional therapy for patients carrying the disease-associated genotype."

For more information on this research see: Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease. American Journal of Clinical Nutrition, 2014;99(2):378-383. American Journal of Clinical Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA (see also Inflammatory Bowel Diseases).

Our news correspondents report that additional information may be obtained by contacting M.A. Shaghaghi, University of Manitoba, Dept. of Internal Med, Winnipeg, MB R3T 2N2, Canada. Additional authors for this research include C.N. Bernstein, A.S. Leon, H. El-Gabalawy and P. Eck.

Keywords for this news article include: Canada, Winnipeg, Manitoba, Genetics, Crohn's Disease, Gastroenteritis, Gastroenterology, Risk and Prevention, North and Central America, Digestive System Diseases, Gastrointestinal Diseases, Inflammatory Bowel Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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