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Findings on Asthma Detailed by Investigators at Florida Atlantic University

Immunotherapy Weekly


By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Researchers detail new data in Obstructive Lung Diseases. According to news originating from Boca Raton, Florida, by NewsRx correspondents, research stated, "Vitamin D suppresses inflammation and vitamin D deficiency is linked to the severity of asthma symptoms. T-helper type 9 (T(H)9) cells are important in the pathogenesis, yet the effects of vitamin D on this subset of inflammatory T-helper cells from patients with chronic asthma is unknown."

Our news journalists obtained a quote from the research from Florida Atlantic University, "To determine the effects of vitamin D and dexamethasone on T(H)9 memory cells from adults with chronic persistent asthma and on a recall response to dust mite allergen. T-helper memory cells were cultured with cytokines that drive T(H)9 polarization with vitamin D and/or dexamethasone. Peripheral blood mononuclear cells (PBMCs) from patients with radioallergosorbent test results for house dust mite were stimulated with allergen in the presence or absence of vitamin D. Intracellular cytokines, transcription factors, and identification of cell surface phenotypic markers were determined by flow cytometry. Vitamin D decreased interleukin (IL)-9, IL-5, and IL-8 but increased IL-13(+) cells in T(H)9 cultures. Transcription factors PU.1 and interferon regulatory factor 4 were downregulated by vitamin D but not GATA3 and c-MAF. When PBMCs from patients with positive radioallergosorbent test results were stimulated with dust mite allergen, vitamin D decreased IL-9, IL-5, and IL-13 in T-helper cells (CD4(+)). T(H)9 cells present in a recall response were classically T(H)2 (CD294(+)), and polarization by transforming growth factor-beta and IL-4 altered that phenotype. Vitamin D decreased inflammatory cytokine profiles in T(H)9 memory cells and CD4(+) cells stimulated with dust mite allergen."

According to the news editors, the research concluded: "Vitamin D is additive with dexamethasone in decreasing inflammatory cytokine production from T-cell subsets implicated in asthma."

For more information on this research see: Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Annals of Allergy Asthma & Immunology, 2014;112(2):154-162. Annals of Allergy Asthma & Immunology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA (see also Obstructive Lung Diseases).

The news correspondents report that additional information may be obtained from P. Keating, Florida Atlantic Univ, Boca Raton, FL 33431, United States. Additional authors for this research include A. Munim and J.X. Hartmann.

Keywords for this news article include: Asthma, Florida, Boca Raton, United States, Bronchial Diseases, North and Central America, Obstructive Lung Diseases, Respiratory Tract Diseases, Respiratory Hypersensitivity

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