NIH Urges Older Americans to Protect Their Kidneys
Targeted News Service
In recognition of
Kidney Disease Education Program
The kidneys' main job is to filter wastes and extra water from the blood to make urine. Chronic kidney disease (CKD) is defined by decreased kidney function and/or evidence of kidney damage, usually marked by protein in the urine.
Age is also a major risk factor for kidney disease. With advancing years, kidney function generally declines, resulting in increased vulnerability of the older kidney to acute injury and CKD. As the kidney ages, filtering capacity decreases, the overall amount of kidney tissue may decrease, and the blood vessels that supply the kidney may narrow, further reducing the capacity of the kidneys to filter blood. This decline in kidney function with age is nearly universal, but occurs at different rates in different people. Conditions such as high blood pressure, smoking and diabetes can accelerate these changes.
Because healthy people have significant reserve kidney function, most age-related decline in kidney function does not make an older person feel or function any differently. However, it is important for older adults and their care providers to know whether kidney function is reduced. Moreover, if kidney function appears to be declining at a rate faster than expected, reversible or treatable causes might be identified to slow the process and preserve kidney function.
Regardless of whether the cause is aging, disease, or both, complications from certain medications increase as kidney function declines. The level of some medicines in the blood may increase because impaired kidneys are less able to eliminate them. The kidneys may also become more sensitive to certain medications. For example, non-steroidal anti-inflammatory drugs such as ibuprofen, some antibiotics, and x-ray contrast agents may be more likely to cause acute kidney injury.
There is a significant need to educate the aging population and their health care providers about ways to prevent kidney injury. Encouraging older Americans to know their level of kidney function and be mindful of the medicines they take is an important step toward reducing the growing rates of kidney injury in
As the U.S. population ages and rates of diabetes rise, the number of older Americans at risk for kidney disease will increase. Research has helped us to better understand the impact of aging on kidney function and how aging-related changes increase older adults' vulnerability to acute and chronic kidney disease. NIDDK and NIA currently support several research initiatives to advance knowledge about age-related kidney function decline and approaches to prevent and treat CKD in older people.
We are learning a great deal about kidney disease in older adults, but more research needs to be done. The NIDDK and the NIA look forward to conducting and promoting research to reduce the burden of kidney disease in older people.
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