Cell-saving drugs could reduce brain damage after stroke
Global Data Point
Until now, many scientists believed that blood flow within the brain was solely controlled by changes in the diameter of arterioles, blood vessels that branch out from arteries into smaller capillaries. The latest research reveals that the brain's blood supply is in fact chiefly controlled by the narrowing or widening of capillaries as pericytes tighten or loosen around them.
The study, published this week in Nature, shows not only that pericytes are the main regulator of blood flow to the brain, but also that they tighten and die around capillaries after stroke. This significantly impairs blood flow in the long term, causing lasting damage to brain cells. The team of scientists from UCL,
"At present, clinicians can remove clots blocking blood flow to the brain if stroke patients reach hospital early enough," explains Professor
"This discovery offers radically new treatment approaches for stroke," says study co-author Professor
The new research also gives insight into the mechanisms underlying the use of functional magnetic resonance imaging to detect blood flow changes in the brain.
"Functional imaging allows us to see the activity of nerve cells within the human brain but until now we didn't quite know what we were looking at," explains Professor Attwell. "We have shown that pericytes initiate the increase in blood flow seen when nerve cells become active, so we now know that functional imaging signals are caused by a pericyte-mediated increase of capillary diameter. Knowing exactly what functional imaging shows will help us to better understand and interpret what we see."