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Findings from Kyung Hee University Has Provided New Data on Inflammation

Health & Medicine Week


By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Inflammation have been published. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "Resveratrol (RSV) regulates NAD bioavailability and sirtuin-related metabolism, which relates to aging, metabolic syndrome and non-alcoholic fatty liver disease. The purpose of this study was to investigate the effects of resveratrol on hepatic metaflammation in a rodent model of high-fat (HF) diet-induced obesity (DIO)."

Our news editors obtained a quote from the research from Kyung Hee University, "DIO was induced in a subset of mice given an HF diet (45% kcal fat). After 6 weeks of HF diet feeding, RSV was delivered via an osmotic pump for 4 weeks. The experimental groups were as follows: 1) lean control fed with a standard diet, 2) HF diet-induced obese control, and 3) HF_RSV (8 mg/kg/day). After 4 weeks of each treatment, blood and liver tissues were collected and the indices of glucose control, serum and liver triglyceride (TG), sirtuin pathway, inflammation, and NOD-like receptor family, pryin domain containing 3 (NLRP3) inflammasome were analyzed. Body weight and food intake were not altered by administering resveratrol. Glucose control was impaired, and serum and liver TG levels were increased by the HF diet. Hepatic inflammation was aggravated in mice fed with the HF diet, as shown by the increased levels of the pro-inflammatory markers interleukin-1 (IL-1), IL-6 and tumor necrosis factor-alpha in the liver. However, resveratrol administration significantly improved glucose control, and serum and liver TG contents. Also, resveratrol treatment reduced the levels of the pro-inflammatory markers. These improvements were accompanied by alterations in sirtuin pathway and NLRP3 inflammasome activation."

According to the news editors, the research concluded: "These results demonstrate that resveratrol ameliorates hepatic metaflammation, accompanied by alterations in NLRP3 inflammasome."

For more information on this research see: Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation. Metabolism-Clinical and Experimental, 2014;63(5):693-701. Metabolism-Clinical and Experimental can be contacted at: W B Saunders Co-Elsevier Inc, 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, PA 19103-2899, USA (see also Inflammation).

The news editors report that additional information may be obtained by contacting S.J. Yang, Kyung Hee Univ, Dept. of Food & Nutr, Seoul, South Korea.

Keywords for this news article include: Asia, Seoul, South Korea, Inflammation

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