Studies from State University Have Provided New Information about Complementary and Alternative Medicine (Cytotoxic effects of Euterpe oleracea Mart. in malignant cell lines)
By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Health and Medicine. According to news reporting from Rio de Janeiro, Brazil, by NewsRx journalists, research stated, "Euterpe oleracea Mart., a plant from the Amazon region, is commonly known as acai or jucara; it has high nutritional value and elevated levels of lipids, proteins, and minerals. Acai is an abundant and much consumed fruit by the Amazon local population, and studies have demonstrated that it is rich in phytochemicals with antioxidant, anti-inflammatory, and anticancer activities."
The news correspondents obtained a quote from the research from State University, "Therefore, the aim of this study was to test this plant for anticancer activity in different human malignant cell lines. Cell lines derived from breast and colorectal adenocarcinomas were treated with 10, 20, and 40 mu g/mL of bark, seed, and total acai fruit hydroalcoholic extracts for 24 and 48 h. After treatment, cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, and cell morphological features were observed by light and transmission electron microscopy. The type of cell death was also evaluated. The data were analyzed statistically by one-way analysis of variance (ANOVA), followed by Dunnett's or Tukey's post hoc tests, as appropriate. We observed that of all the cell lines tested, MCF-7 was the only line that responded to acai treatment. The extracts caused significant reduction (p < 0.01) in cell viability and altered cell morphological features by inducing the appearance of autophagic vacuoles, as observed by transmission electron microscopy. Furthermore, increased expression of LC3BII, a protein marker of autophagosome formation, was observed by western blotting. Caspase Glo ™ assays and morphologic observations by DAPI nuclear staining and transmission electron microscopy did not indicate any apoptotic events. The present study demonstrated that acai possesses antitumorigenic potential in the MCF-7 cell line. Further studies are needed to identify the compound (s) responsible for this cytotoxic activity and the molecular target in the cell."
According to the news reporters, the research concluded: "This discovery of the anticancer potential of acai may help in the development of chemopreventive drugs and may have therapeutic effects in the treatment of breast cancer."
For more information on this research see: Cytotoxic effects of Euterpe oleracea Mart. in malignant cell lines. BMC Complementary and Alternative Medicine, 2014;14():1-9. BMC Complementary and Alternative Medicine can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; BMC Complementary and Alternative Medicine - www.biomedcentral.com/bmccomplementalternmed/)
Our news journalists report that additional information may be obtained by contacting D.F. Silva, Univ Estado Rio De Janeiro, Dept. of Pharmacol, Lab Pharmacol & Psychobiol, Rio De Janeiro, Brazil. Additional authors for this research include F.C.B. Vidal, D. Santos, M.C.P. Costa, J.A. Morgado-Diaz, M. Nascimento and R.S. de Moura (see also Health and Medicine).
Keywords for this news article include: Brazil, South America, Rio de Janeiro, Health and Medicine
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