Findings from University of Oklahoma Yields New Findings on Cholesterol (Freeze-Dried Strawberries Lower Serum Cholesterol and Lipid Peroxidation in Adults with Abdominal Adiposity and Elevated Serum Lipids)
By a News Reporter-Staff News Editor at Food Weekly News -- Investigators publish new report on Cholesterol. According to news reporting from Oklahoma City, Oklahoma, by VerticalNews journalists, research stated, "Dietary flavonoid intake, especially berry flavonoids, has been associated with reduced risks of cardiovascular disease (CVD) in large prospective cohorts. Few clinical studies have examined the effects of dietary berries on CVD risk factors."
The news correspondents obtained a quote from the research from the University of Oklahoma, "We examined the hypothesi that freeze-dried strawberries (FDS) improve lipid and lipoprotein profiles and lower bio-markers of inflammation and lipid oxidation in adults with abdominal adiposity and elevated serum lipids. In a randomized dose-response controlled trial, 60 volunteers [5 men and 55 women; aged 49 +/- 10 y; BMI: 36 +/- 5 kg/m(2) (means +/- SDs)] were assigned to consume 1 of the following 4 beverages for 12 wk: 1) low-dose FDS (LD-FDS; 25 g/d); 2) low-dose control (LD-C); 3) high-dose FDS (HD-FDS, 50 g/d); and 4) high-dose control (HD-C). Control beverages were matched for calories and total fiber. Blood draws, anthropometrics, blood pressure, and dietary data were collected at screening (0 wk) and after 12-wk intervention. Dose-response analyses revealed significantly greater decreases in serum total and LDL cholesterol and nuclear magnetic resonance (NMR) derived small LDL particle concentration in HD-FDS [33 +/- 6 mg/dL, 28 +/- 7 mg/dL, and 301 +/- 78 nmol/L, respectively (means +/- SEMs)] vs. LD-FDS (-3 +/- 11 mg/dL, -3 +/- 9 mg/dL, and -28 +/- 124 nmol/L, respectively) over 12 wk (0-12 wk; all P< 0.05). Compared with controls, only the decreases in total and LDL cholesterol in HD-FDS remained significant vs. HD-C (0.7 +/- 12 and 1.4 +/- 9 mg/dL, respectively) over 12 wk (0-12 wk; all P< 0.05). Both doses of strawberries showed a similar decrease in serum malondialdehyde at 12 wk (LD-FDS: 1.3 +/- 0.2 mu mol/L; HD-FDS: 1.2 +/- 0.1 mu mol/L) vs. controls (LD-C: 2.1 +/- 0.2 mu mol/L; HD-C: 2.3 +/- 0.2 mu mol/L) (P < 0.05). In general, strawberry intervention did not affect any measures of adiposity, blood pressure, glycemia, and serum concentrations of HDL cholesterol and triglycerides, C-reactive protein, and adhesion molecules. Thus, HD-FDS exerted greater effects in lowering serum total and LDL cholesterol and NMR-derived small LDL particles vs. LD-FDS in the 12-wk study. These findings warrant additional investigation in larger trials."
According to the news reporters, the research concluded: "This trial was registered at clinicaltrials.gov as NCT01883401."
For more information on this research see: Freeze-Dried Strawberries Lower Serum Cholesterol and Lipid Peroxidation in Adults with Abdominal Adiposity and Elevated Serum Lipids. Journal of Nutrition, 2014;144(6):830-837. Journal of Nutrition can be contacted at: Amer Soc Nutrition-Asn, 9650 Rockville Pike, Bethesda, MD 20814, USA. (Hindawi Publishing - www.hindawi.com; Journal of Nutrition - www.hindawi.com/journals/jnume/)
Our news journalists report that additional information may be obtained by contacting A. Basu, University of Oklahoma, Hlth Sci Center, Sect Diabet & Endocrinol, Oklahoma City, OK, United States. Additional authors for this research include N.M. Betts, A. Nguyen, E.D. Newman, D.X. Fu and T.J. Lyons.
Keywords for this news article include: Food, Beverage, Hemodynamics, Oklahoma City, United States, Blood Pressure, LDL Cholesterol, LDL Lipoproteins, North and Central America
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