Reports Outline Calcium-Binding Proteins Findings from University of Auvergne (The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity)
By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Carrier Proteins is now available. According to news originating from Clermont Ferrand, France, by NewsRx correspondents, research stated, "Scope: Flavonoids represent a group of polyphenolic compounds commonly found in daily nutrition with proven health benefits. Among this group, the flavonol fisetin has been previously shown to protect bone by repressing osteoclast differentiation."
Our news journalists obtained a quote from the research from the University of Auvergne, "In the present study, we investigated the role of fisetin in regulating osteoblasts physiology. In vivo mice treated with LPSs exhibited osteoporosis features associated with a dramatic repression of osteoblast marker expression. In this model, inhibition of osteocalcin and type I collagen alpha 1 transcription was partially countered by a daily consumption of fisetin. Interestingly, in vitro, fisetin promoted both osteoblast alkaline phosphatase activity and mineralization process. To decipher how fisetin may exert its positive effect on osteoblastogenesis, we analyzed its ability to control the runt-related transcription factor 2 (Runx2), a key organizer in developing and maturing osteoblasts. While fisetin did not impact Runx2 mRNA and protein levels, it upregulated its transcriptional activity. Actually, fisetin stimulated the luciferase activity of a reporter plasmid driven by the osteocalcin gene promoter that contains Runx2 binding sites and promoted the mRNA expression of osteocalcin and type I collagen alpha 1 targets."
According to the news editors, the research concluded: "Bone sparing properties of fisetin also rely on its positive influence on osteoblast differentiation and activity."
For more information on this research see: The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity. Molecular Nutrition & Food Research, 2014;58(6):1239-1248. Molecular Nutrition & Food Research can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Molecular Nutrition & Food Research - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-4133)
The news correspondents report that additional information may be obtained from L. Lootoing, Univ Auvergne, Clermont Univ, Unite Nutr Humaine, Clermont Ferrand, France. Additional authors for this research include M.J. Davicco, P. Lebecque, Y. Wittrant and V. Coxam (see also Carrier Proteins).
Keywords for this news article include: France, Europe, Osteocalcin, Bone Research, Clermont Ferrand, Carrier Proteins, Calcium-Binding Proteins
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