Compounded outcomes associated with comorbid Alzheimer's disease & cerebrovascular disease
The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research & Therapy, have potentially significant implications for patients with both disorders.
Both papers studied CVD in Alzheimer's disease mouse models using different lifestyle factors.
According to Wilcock, both papers came to similar conclusions.
"We found that, while the primary Alzheimer's pathologies were unchanged, the learning and memory outcomes were significantly worse. In other words, in our mouse models, the cognitive effects of Alzheimer's disease combined with cerebrovascular disease were compounded both in terms of severity and the speed of decline," Wilcock says.
Murphy emphasizes the significance of the findings, particularly since approximately 40% of Alzheimer's patients also have cerebrovascular disease.
"We are really excited about these results," Murphy said. "Until now, we have had almost no way to study how Alzheimer's and cerebrovascular disease interact. These new mouse models give us a way to test ideas about the disease, and ultimately develop ways to treat it."
Keywords for this news article include: Dementia, Tauopathies, Brain Diseases, Alzheimer Disease,
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